Mass spectrometric detection of tissue proteins in plasma

Hui Zhang, Alvin Y. Liu, Paul Loriaux, Bernd Wollscheid, Yong Zhou, Julian D. Watts, Ruedi Aebersold

Research output: Contribution to journalArticlepeer-review

154 Scopus citations


It has long been thought that blood plasma could serve as a window into the state of one's organs in health and disease because tissue-derived proteins represent a significant fraction of the plasma proteome. Although substantial technical progress has been made toward the goal of comprehensively analyzing the blood plasma proteome, the basic assumption that proteins derived from a variety of tissues could indeed be detectable in plasma using current proteomics technologies has not been rigorously tested. Here we provide evidence that such tissue-derived proteins are both present and detectable in plasma via direct mass spectrometric analysis of captured glycopeptides and thus provide conceptual basis for plasma protein biomarker discovery and analysis.

Original languageEnglish (US)
Pages (from-to)64-71
Number of pages8
JournalMolecular and Cellular Proteomics
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology


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