Markers of inflammation, Vitamin E and peripheral nervous system function. The InCHIANTI study

Angelo Di Iorio, Antonio Cherubini, Stefano Volpato, Eleonora Sparvieri, Fulvio Lauretani, Claudio Franceschi, Umberto Senin, Giuseppe Abate, Roberto Paganelli, Antonio Martin, Cristina Andres-Lacueva, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Background: Aging of the peripheral nervous system is associated with several morphologic and functional changes, including a decrease of the nerve conduction velocity. There is evidence that these changes contribute to age-related-decline in muscle strength, sensory discrimination, and autonomic responses. The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity. Methods: We measured motor nerve conduction velocity of the right superficial peroneal nerve using a standard neurophysiologic technique in a population-based sample of subjects aged between 20 and 103 years old enrolled in the InCHIANTI study. Results: Average conduction velocities in the peripheral nerve decreased linearly with age in both sexes. We found that diabetes, cognitive impairment, uric acid, sIL-6R and α-tocopherol were significant predictors of nerve conduction velocity independently of the potential confounding effect of age, sex, sex × age interaction term, height, lymphocytes, neutrophils number, α1 and α2-globulin serum protein. Conclusions: Our findings are consistent with the hypothesis that inflammation and inadequate antioxidant defenses are associated with accelerated decline of nerve conduction velocity over the aging process.

Original languageEnglish (US)
Pages (from-to)1280-1288
Number of pages9
JournalNeurobiology of Aging
Issue number9
StatePublished - Sep 2006
Externally publishedYes


  • Aging
  • Inflammation
  • Peripheral nervous system
  • Vitamin E

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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