Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Ann B. Ragin; Ying Wu; Renee Ochs; Hongyan Du; Leon G. Epstein; Katherine Conant; Justin C. McArthur

doi:10.1007/s13365-011-0018-5

Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Ann B. Ragin, Ying Wu, Renee Ochs, Hongyan Du, Leon G. Epstein, Katherine Conant, Justin C. McArthur

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

Original language	English (US)
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of neurovirology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s13365-011-0018-5
State	Published - Apr 2011

Keywords

HIV-dementia
MMP-1
MMP-7
NeuroAIDS
Quantitative MRI

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.1007/s13365-011-0018-5

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title = "Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection",

abstract = "Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.",

keywords = "HIV-dementia, MMP-1, MMP-7, NeuroAIDS, Quantitative MRI",

author = "Ragin, {Ann B.} and Ying Wu and Renee Ochs and Hongyan Du and Epstein, {Leon G.} and Katherine Conant and McArthur, {Justin C.}",

note = "Funding Information: This work was supported by National Institutes of Health grants: MH66705 (ABR), MH080636 (ABR), NS052580 (KC), and MH075673 (JCM). The NEAD cohort was supported by NS044807 (JCM) and NS049465 (JCM). The authors thank Linda Reisberg, Pippa Storey, and the NEAD consortium. ",

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doi = "10.1007/s13365-011-0018-5",

language = "English (US)",

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AU - Ragin, Ann B.

AU - Wu, Ying

AU - Ochs, Renee

AU - Du, Hongyan

AU - Epstein, Leon G.

AU - Conant, Katherine

AU - McArthur, Justin C.

N1 - Funding Information: This work was supported by National Institutes of Health grants: MH66705 (ABR), MH080636 (ABR), NS052580 (KC), and MH075673 (JCM). The NEAD cohort was supported by NS044807 (JCM) and NS049465 (JCM). The authors thank Linda Reisberg, Pippa Storey, and the NEAD consortium.

PY - 2011/4

Y1 - 2011/4

N2 - Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

AB - Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

KW - HIV-dementia

KW - MMP-1

KW - MMP-7

KW - NeuroAIDS

KW - Quantitative MRI

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Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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