Marfan Syndrome: A Clinical Update

Adam D. Bitterman, Paul David Sponseller

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Marfan syndrome is a connective tissue disorder that can affect many organ systems. Affected patients present with orthopaedic manifestations of the syndrome during all phases of life. Pain caused by musculoskeletal abnormalities often requires definitive orthopaedic treatment. Orthopaedic surgeons must understand the phenotypes of Marfan syndrome so they can recognize when screening is warranted and can appropriately address the skeletal manifestations. Through medical advancements, patients with Marfan syndrome are living longer and more active lives. Knowledge of the latest diagnostic criteria for the disorder, as well as of advances in understanding the skeletal phenotype, clinical trials of medication therapy, and lifestyle considerations is important for orthopaedic surgeons who treat these patients because these clinicians often are the first to suspect Marfan syndrome and recommend screening.

Original languageEnglish (US)
Pages (from-to)603-609
Number of pages7
JournalJournal of the American Academy of Orthopaedic Surgeons
Issue number9
StatePublished - Sep 1 2017


  • aorta
  • aortic aneurysm
  • dislocated lenses
  • flat foot deformity
  • Marfan syndrome
  • pectus carinatum
  • pectus excavatum
  • pes planus
  • scoliosis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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