Mapping of the internal structure of human habenula with ex vivo MRI at 7T

Barbara Strotmann, Carsten Kögler, Pierre Louis Bazin, Marcel Weiss, Arno Villringer, Robert Turner

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The habenula is a small but important nucleus located next to the third ventricle in front of the pineal body. It helps to control the human reward system and is considered to play a key role in emotion, showing increased activation in major depressive disorders. Its dysfunction may underlie several neurological and psychiatric disorders. It is now possible to visualize the habenula and its anatomical subdivisions-medial habenula (MHB) and lateral habenula (LHB)-using MR techniques. The aim of this study was to further differentiate substructures within human lateral habenula (LHB) using ex vivo ultra-high field MR structural imaging, distinguishing between a medial part (m-LHB) and a lateral part (l-LHB). High resolution T1w images with 0.3-mm isotropic resolution and T2*w images with 60-micrometer isotropic resolution were acquired on a 7T MR scanner and quantitative maps of T1 and T2* were calculated. Cluster analysis of image intensity was performed using the Fuzzy and Noise Tolerant Adaptive Segmentation Method (FANTASM) tool. Ultra-high resolution structural MRI of ex vivo brain tissue at 7T provided sufficient SNR and contrast to discriminate the medial and lateral habenular nuclei. Heterogeneity was observed in the lateral habenula (LHB) nuclei, with clear distinctions between lateral and medial parts (m-LHB, l-LHB) and with the neighboring medial habenula (MHB). Clustering analysis based on the T1 and T2* maps strongly showed 4-6 clusters as subcomponents of lateral and medial habenula.

Original languageEnglish (US)
Article number878
JournalFrontiers in Human Neuroscience
Issue numberDEC
StatePublished - Dec 23 2013
Externally publishedYes


  • 7T
  • Ex vivo
  • Habenular nuclei
  • Human habenula
  • Lateral habenula
  • MRI
  • Medial habenula

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience


Dive into the research topics of 'Mapping of the internal structure of human habenula with ex vivo MRI at 7T'. Together they form a unique fingerprint.

Cite this