Mapping Interests in Event-Driven and Long-Acting Pre-exposure Prophylaxis Formulations onto the HIV Risk Environment of Street-Based Female Sex Workers: A Latent Class Analysis

Joseph G. Rosen, Ju Nyeong Park, Kristin E. Schneider, Rebecca Hamilton White, S. Wilson Beckham, Jennifer L. Glick, Katherine H.A. Footer, Susan G. Sherman

Research output: Contribution to journalArticlepeer-review

Abstract

Despite growing availability, HIV pre-exposure prophylaxis (PrEP) uptake and adherence remains suboptimal among female sex workers (FSW) in the United States. Using cross-sectional data from a survey of 236 street-based cisgender FSW in Baltimore, Maryland, we examined interest in event-driven and long-acting PrEP formulations. Latent class analysis identified discrete patterns of interest in five novel PrEP agents. Multinomial latent class regression then examined factors associated with probabilistic class membership. A three-class solution emerged as the best-fit latent class model: Injectable Acceptors (~ 24% of sample), Universal Acceptors (~ 18%), and Non-Acceptors (~ 58%). Compared to Non-Acceptors, Universal Acceptors had significantly (p < 0.05) higher odds of reporting condomless vaginal sex with clients, client condom coercion, and client-perpetrated physical violence. Relative to Non-Acceptors, Injectable Acceptors were distinguished by significantly higher rates of condomless vaginal sex with clients and injection drug use. Expanding PrEP options for FSW could help overcome barriers to PrEP initiation and persistence.

Original languageEnglish (US)
Pages (from-to)1992-2002
Number of pages11
JournalAIDS and behavior
Volume26
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • Biomedical HIV prevention
  • HIV pre-exposure prophylaxis
  • Injection drug use
  • Sex work
  • United States

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

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