Manipulation of opiate activity in the amygdala alters memory processes

M. Gallagher; B. S. Kapp

doi:10.1016/0024-3205(78)90565-9

Manipulation of opiate activity in the amygdala alters memory processes

M. Gallagher
, B. S. Kapp

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

Original language	English (US)
Pages (from-to)	1973-1977
Number of pages	5
Journal	Life Sciences
Volume	23
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(78)90565-9
State	Published - Nov 9 1978
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(78)90565-9

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title = "Manipulation of opiate activity in the amygdala alters memory processes",

abstract = "The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.",

author = "M. Gallagher and Kapp, \{B. S.\}",

note = "Funding Information: *Supported by NIH grant R03 01577-01, and a Research Scientist Development Award K02 MH00118 (NIMH) to B .S .R .",

year = "1978",

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AU - Gallagher, M.

AU - Kapp, B. S.

N1 - Funding Information: *Supported by NIH grant R03 01577-01, and a Research Scientist Development Award K02 MH00118 (NIMH) to B .S .R .

PY - 1978/11/9

Y1 - 1978/11/9

N2 - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

AB - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

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UR - https://www.scopus.com/pages/publications/0018167052#tab=citedBy

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DO - 10.1016/0024-3205(78)90565-9

M3 - Article

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AN - SCOPUS:0018167052

SN - 0024-3205

VL - 23

SP - 1973

EP - 1977

JO - Life Sciences

JF - Life Sciences

IS - 19

ER -

Manipulation of opiate activity in the amygdala alters memory processes

Abstract

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