Mania after brain injury: Neuroradiological and metabolic findings

Sergio E. Starkstein; Helen S. Mayberg; Marcelo L. Berthier; Paul Fedoroff; Thomas R. Price; Robert F. Dannals; Henry N. Wagner; Ramon Leiguarda; Robert G. Robinson

doi:10.1002/ana.410270612

Mania after brain injury: Neuroradiological and metabolic findings

Sergio E. Starkstein, Helen S. Mayberg, Marcelo L. Berthier, Paul Fedoroff, Thomas R. Price, Robert F. Dannals, Henry N. Wagner, Ramon Leiguarda, Robert G. Robinson

School of Medicine

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). while the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a ¹⁸fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.

Original language	English (US)
Pages (from-to)	652-659
Number of pages	8
Journal	Annals of neurology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1002/ana.410270612
State	Published - Jun 1990

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Mania after brain injury: Neuroradiological and metabolic findings",

abstract = "We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). while the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a 18fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.",

author = "Starkstein, {Sergio E.} and Mayberg, {Helen S.} and Berthier, {Marcelo L.} and Paul Fedoroff and Price, {Thomas R.} and Dannals, {Robert F.} and Wagner, {Henry N.} and Ramon Leiguarda and Robinson, {Robert G.}",

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AU - Starkstein, Sergio E.

AU - Mayberg, Helen S.

AU - Berthier, Marcelo L.

AU - Fedoroff, Paul

AU - Price, Thomas R.

AU - Dannals, Robert F.

AU - Wagner, Henry N.

AU - Leiguarda, Ramon

AU - Robinson, Robert G.

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AB - We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). while the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a 18fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.

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Mania after brain injury: Neuroradiological and metabolic findings

Abstract

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