Management of high-risk populations with locally advanced prostate cancer

Masood A. Khan, Alan W. Partin

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Prostate cancer that extends beyond the confines of the prostatic gland on clinical and/or radiographic assessment, without evidence of lymph node or distant metastases, is regarded as locally advanced. The locally advanced prostate cancer patient population consists of a heterogeneous group of men, some of whom have tumors that may be amenable to primary curative intent with local definitive therapy associated with acceptable long-term cancer control rates. In order to optimally manage this group of patients, it is important to be able to recognize who is at a high risk of tumor recurrence after primary local therapy. In this brief review, we discuss the factors that contribute to the prediction of high risk in populations with locally advanced disease and the treatment options available.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
Issue number3
StatePublished - 2003


  • Locally advanced prostate cancer
  • Management
  • Risk factors

ASJC Scopus subject areas

  • General Medicine


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