Management of Acanthamoeba Keratitis: A Case Report and Review of the Literature

Lawrence W. Hirst, W. Richard Green, William Merz, Cindy Kaufmann, G. S. Visvesvara, Allan Jensen, Malin Howard

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


A recalcitrant corneal ulcer resulted in an extensive corneal opacity requiring penetrating keratoplasty. Histopathologic studies and subsequent cultures established the diagnosis of Acanthamoeba keratitis. A second transplant was performed due to a culture-proven recurrence of the keratitis in both the recipient and the graft, with progressive thinning. This has remained clear for six months on systemic ketoconazole and topical miconazole drops. This case demonstrates the difficulty in initial diagnosis of Acanthamoeba keratitis and the apparent successful medical control of the infection despite transplantation into an infected recipient bed.

Original languageEnglish (US)
Pages (from-to)1105-1111
Number of pages7
Issue number9
StatePublished - 1984


  • Acanthamoeba keratitis
  • amoebic uveitis
  • corneal transplant
  • minor ocular trauma

ASJC Scopus subject areas

  • Ophthalmology


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