Management and Recommendations for Future Pregnancy in Patients with Early-Stage Endometrial Cancer: A Survey of Gynecologic Oncologists and Reproductive Endocrinology and Infertility Specialists

Xiaoyue M. Guo, Edward J. Tanner, Mary Ellen Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To determine how young patients with early-stage endometrial cancer are counseled regarding fertility preserving therapy and pregnancy options by gynecologic oncology and reproductive endocrinology and infertility (REI) providers. Methods: Anonymous online survey of Society of Gynecology Oncology (SGO) and the Society for Reproductive Endocrinology and Infertility (SREI) members; data were analyzed using chi-square and t-Tests. Results: Twelve percent (169/1433) of SGO and 6.5% (60/927) of SREI members responded to the survey request. Most providers manage fewer than 10 fertility preservation patients annually. All gynecologic oncologists offer conservative management to patients with grade 1 endometrial cancer without evidence of invasion, and 40% would offer it to patients with grade 2 or <50% invasion. Magnetic resonance imaging was the most common method of assessing invasion, and the progesterone intrauterine device was the preferred first-line treatment. Two-Thirds of providers would recommend hysterectomy if no endometrial response was noted by 12 months, two-Thirds would continue conservative management for more than a year if a partial response was noted, and 70% would recommend hysterectomy after a patient completes childbearing. Comparatively, 60% of REI providers would recommend hysterectomy after childbearing. More gynecologic oncologists than REI providers recommend attempting spontaneous conception and for longer durations before initiating fertility treatments. Conclusion: Heterogeneous management styles exist among and between gynecologic oncology and REI providers for patients with early-stage endometrial cancer desiring future pregnancy. Improved guidelines are needed regarding treatment and monitoring surrounding trials of conception and pregnancy.

Original languageEnglish (US)
Pages (from-to)654-660
Number of pages7
JournalJournal of Adolescent and Young Adult Oncology
Volume10
Issue number6
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • Endometrial cancer
  • Fertility preservation
  • Gynecologic cancer
  • Oncofertility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology

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