Mammary ductal carcinoma with comedo pattern in a rhesus macaque

Joanne M. Smith, Srinivas S. Rao, Kyle C. Stump, Cinzia Benazzi, Giuseppe Sarli, Louis J. Detolla

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, tabulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalContemporary Topics in Laboratory Animal Science
Issue number4
StatePublished - Jul 2005
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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