TY - JOUR
T1 - Male circumcision and mycoplasma genitalium infection in female partners
T2 - A randomised trial in rakai, uganda
AU - Tobian, Aaron A.R.
AU - Gaydos, Charlotte
AU - Gray, Ronald H.
AU - Kigozi, Godfrey
AU - Serwadda, David
AU - Quinn, Nicole
AU - Grabowski, Mary K.
AU - Musoke, Richard
AU - Ndyanabo, Anthony
AU - Nalugoda, Fred
AU - Wawer, Maria J.
AU - Quinn, Thomas C.
PY - 2014
Y1 - 2014
N2 - Objective: Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods: HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results: Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48to 2.12, p=0.97). Conclusions: Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
AB - Objective: Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods: HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results: Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48to 2.12, p=0.97). Conclusions: Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
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U2 - 10.1136/sextrans-2013-051293
DO - 10.1136/sextrans-2013-051293
M3 - Article
C2 - 24259189
AN - SCOPUS:84897648296
SN - 1368-4973
VL - 90
SP - 150
EP - 154
JO - Sexually transmitted infections
JF - Sexually transmitted infections
IS - 2
ER -