Male circumcision and mycoplasma genitalium infection in female partners: A randomised trial in rakai, uganda

Aaron A.R. Tobian, Charlotte Gaydos, Ronald H. Gray, Godfrey Kigozi, David Serwadda, Nicole Quinn, Mary K. Grabowski, Richard Musoke, Anthony Ndyanabo, Fred Nalugoda, Maria J. Wawer, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods: HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results: Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48to 2.12, p=0.97). Conclusions: Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalSexually transmitted infections
Issue number2
StatePublished - 2014

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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