Male circumcision and herpes simplex virus type 2 infection in female partners: A randomized trial in Rakai, Uganda

Aaron A.R. Tobian; Godfrey Kigozi; Andrew D. Redd; David Serwadda; Xiangrong Kong; Amy Oliver; Fred Nalugoda; Thomas C. Quinn; Ronald H. Gray; Maria J. Wawer

doi:10.1093/infdis/jir767

Male circumcision and herpes simplex virus type 2 infection in female partners: A randomized trial in Rakai, Uganda

Aaron A.R. Tobian, Godfrey Kigozi, Andrew D. Redd, David Serwadda, Xiangrong Kong, Amy Oliver, Fred Nalugoda, Thomas C. Quinn, Ronald H. Gray, Maria J. Wawer

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26 Scopus citations

Abstract

Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI},. 62-1.49]; P =. 87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI,. 44-1.67]; P =. 62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.

Original language	English (US)
Pages (from-to)	486-490
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	205
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jir767
State	Published - Feb 1 2012

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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@article{50833b9e00964923b4813f4b6cd8616d,

title = "Male circumcision and herpes simplex virus type 2 infection in female partners: A randomized trial in Rakai, Uganda",

abstract = "Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI},. 62-1.49]; P =. 87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI,. 44-1.67]; P =. 62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.",

author = "Tobian, {Aaron A.R.} and Godfrey Kigozi and Redd, {Andrew D.} and David Serwadda and Xiangrong Kong and Amy Oliver and Fred Nalugoda and Quinn, {Thomas C.} and Gray, {Ronald H.} and Wawer, {Maria J.}",

note = "Funding Information: Financial support. The trials were supported by the Bill and Melinda Gates Foundation (22006.02) and the National Institutes of Health (NIH; U1AI51171); this work was supported by the Doris Duke Charitable Foundation (2011036), along with the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, for laboratory support; the Fogarty International Center (5D43TW001508 and D43TW00015), for contributions to training; and the Doris Duke Charitable Foundation, NIH (1K23AI093152-01A1 to A. A. R. T.), and Johns Hopkins University Clinician Scientist Development Award (to A. A. R. T.). Potential conflicts of interest. All authors: No reported conflicts.",

year = "2012",

month = feb,

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doi = "10.1093/infdis/jir767",

language = "English (US)",

volume = "205",

pages = "486--490",

journal = "Journal of Infectious Diseases",

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T1 - Male circumcision and herpes simplex virus type 2 infection in female partners

T2 - A randomized trial in Rakai, Uganda

AU - Tobian, Aaron A.R.

AU - Kigozi, Godfrey

AU - Redd, Andrew D.

AU - Serwadda, David

AU - Kong, Xiangrong

AU - Oliver, Amy

AU - Nalugoda, Fred

AU - Quinn, Thomas C.

AU - Gray, Ronald H.

AU - Wawer, Maria J.

N1 - Funding Information: Financial support. The trials were supported by the Bill and Melinda Gates Foundation (22006.02) and the National Institutes of Health (NIH; U1AI51171); this work was supported by the Doris Duke Charitable Foundation (2011036), along with the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, for laboratory support; the Fogarty International Center (5D43TW001508 and D43TW00015), for contributions to training; and the Doris Duke Charitable Foundation, NIH (1K23AI093152-01A1 to A. A. R. T.), and Johns Hopkins University Clinician Scientist Development Award (to A. A. R. T.). Potential conflicts of interest. All authors: No reported conflicts.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI},. 62-1.49]; P =. 87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI,. 44-1.67]; P =. 62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.

AB - Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI},. 62-1.49]; P =. 87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI,. 44-1.67]; P =. 62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.

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JF - Journal of Infectious Diseases

IS - 3

ER -

Male circumcision and herpes simplex virus type 2 infection in female partners: A randomized trial in Rakai, Uganda

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