Malaria-infected mice are cured by a single dose of novel artemisinin derivatives

Gary H. Posner; Ik Hyeon Paik; Wonsuk Chang; Kristina Borstnik; Sandra Sinishtaj; Andrew S. Rosenthal; Theresa A. Shapiro

doi:10.1021/jm070149m

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives

Gary H. Posner
, Ik Hyeon Paik
, Wonsuk Chang
, Kristina Borstnik
, Sandra Sinishtaj
, Andrew S. Rosenthal
, Theresa A. Shapiro

School of Medicine

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.

Original language	English (US)
Pages (from-to)	2516-2519
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	10
DOIs	https://doi.org/10.1021/jm070149m
State	Published - May 17 2007

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm070149m

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title = "Malaria-infected mice are cured by a single dose of novel artemisinin derivatives",

abstract = "We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.",

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AU - Posner, Gary H.

AU - Paik, Ik Hyeon

AU - Chang, Wonsuk

AU - Borstnik, Kristina

AU - Sinishtaj, Sandra

AU - Rosenthal, Andrew S.

AU - Shapiro, Theresa A.

PY - 2007/5/17

Y1 - 2007/5/17

N2 - We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.

AB - We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.

UR - https://www.scopus.com/pages/publications/34249097684

UR - https://www.scopus.com/pages/publications/34249097684#tab=citedBy

U2 - 10.1021/jm070149m

DO - 10.1021/jm070149m

M3 - Article

C2 - 17439113

AN - SCOPUS:34249097684

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JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 10

ER -

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives

Abstract

ASJC Scopus subject areas

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