Major depression in Down's syndrome

A. C. Warren, S. Holroyd, M. F. Folstein

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Five patients with trisomy 21 (Down's syndrome (DS)), referred to us for evaluation of dementia, were instead found to have major depression. All had shown cognitive and behavioural deterioration and this had led to a mistaken diagnosis of Alzheimer's disease in two. We outline and contrast the features of major depression and Alzheimer's disease in DS, and suggest that electroconvulsive therapy is an effective treatment for major depression in DS.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalBritish Journal of Psychiatry
Issue numberAUG.
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Psychiatry and Mental health


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