Major depression and cardiac autonomic control

Michael Lehofer, Maximilian Moser, Rudolf Hoehn-Saric, Daniel McLeod, Peter Liebmann, Birgit Drnovsek, Sigrun Egner, Gunther Hildebrandt, Hans Georg Zapotoczky

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


We investigated autonomic control of heart rate in patients with major depression, melancholic type. Twenty-three depressed inpatients who were being treated with tricyclic antidepressants and 23 depressed patients who were taking no medications were compared with age- and sex-matched control groups on resting cardiac vagal tone and heart rate. In unmedicated depressed patients, cardiac vagal tone was comparable to that of control subjects, but heart rate was significantly higher. This increase in heart rate may have been due to sympathetic activation caused by anxiety, since the depressed patients were significantly more anxious than the control subjects. Medicated patients exhibited diminished cardiac vagal tone and higher heart rate than unmedicated patients and controls. This was probably due to the anticholinergic effects of the antidepressants. Our findings suggest that cardiac vagal tone is not lower than normal in patients with depression, melancholic type.

Original languageEnglish (US)
Pages (from-to)914-919
Number of pages6
JournalBiological psychiatry
Issue number10
StatePublished - Nov 15 1997
Externally publishedYes


  • Autonomic nervous system
  • Heart rate
  • Major depression
  • Respiratory sinus arrhythmia
  • Tricyclic antidepressants

ASJC Scopus subject areas

  • Biological Psychiatry


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