Major and minor depression in Alzheimer's disease: Prevalence and impact

Constantine G. Lyketsos, Cynthia D. Steele, Lori Baker, Elizabeth Galik, Susan Kopunek, Martin Steinberg, Andrew C. Warren

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


One hundred nine outpatients with Alzheimer's disease (AD) were neuropsychiatrically evaluated and rated on standardized measures of depression, activities of daily living (ADL), nonmood behavioral disturbance, and burdensome events such as serious wandering, falls, and accidents. Distribution of depression scores revealed three patient groups: very few depressive symptoms (51%), minor depression (27%), and major depression (22%). Major depression was associated with substantially greater impairment in ADL, worse nonmood behavioral disturbance (such as aggression), and more frequent serious wandering, even after adjusting for severity of dementia or comorbid health problems. Minor depression was also associated with nonmood behavioral disturbance and wandering. The authors conclude that both major and minor depression are common in AD and produce considerable mood and nonmood morbidity affecting both patients and caregivers. Efforts are warranted to identify and treat depression in AD.

Original languageEnglish (US)
Pages (from-to)556-561
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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