Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport

Rieko Kojima; Yuriko Kakimoto; Shiina Furuta; Kie Itoh; Hiromi Sesaki; Toshiya Endo; Yasushi Tamura

doi:10.1016/j.celrep.2018.12.070

Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport

Rieko Kojima
, Yuriko Kakimoto
, Shiina Furuta
, Kie Itoh
, Hiromi Sesaki
, Toshiya Endo
, Yasushi Tamura

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Kojima et al. show that intra-mitochondrial phospholipid transport by conserved Ups-Mdm35 complexes and MICOS (mitochondrial contact site and cristae organizing system) cooperatively contribute to tubular crista formation, whereas mitochondrial inner membrane fusion by Mgm1 plays a critical role in lamellar crista formation.

Original language	English (US)
Pages (from-to)	518-528.e6
Journal	Cell Reports
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2018.12.070
State	Published - Jan 15 2019

Keywords

cardiolipin
cristae
mitochondria
mitochondrial division
mitochondrial fusion
phospholipid
yeast

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.12.070

Cite this

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title = "Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport",

abstract = "Kojima et al. show that intra-mitochondrial phospholipid transport by conserved Ups-Mdm35 complexes and MICOS (mitochondrial contact site and cristae organizing system) cooperatively contribute to tubular crista formation, whereas mitochondrial inner membrane fusion by Mgm1 plays a critical role in lamellar crista formation.",

keywords = "cardiolipin, cristae, mitochondria, mitochondrial division, mitochondrial fusion, phospholipid, yeast",

author = "Rieko Kojima and Yuriko Kakimoto and Shiina Furuta and Kie Itoh and Hiromi Sesaki and Toshiya Endo and Yasushi Tamura",

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T1 - Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport

AU - Kojima, Rieko

AU - Kakimoto, Yuriko

AU - Furuta, Shiina

AU - Itoh, Kie

AU - Sesaki, Hiromi

AU - Endo, Toshiya

AU - Tamura, Yasushi

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Kojima et al. show that intra-mitochondrial phospholipid transport by conserved Ups-Mdm35 complexes and MICOS (mitochondrial contact site and cristae organizing system) cooperatively contribute to tubular crista formation, whereas mitochondrial inner membrane fusion by Mgm1 plays a critical role in lamellar crista formation.

AB - Kojima et al. show that intra-mitochondrial phospholipid transport by conserved Ups-Mdm35 complexes and MICOS (mitochondrial contact site and cristae organizing system) cooperatively contribute to tubular crista formation, whereas mitochondrial inner membrane fusion by Mgm1 plays a critical role in lamellar crista formation.

KW - cardiolipin

KW - cristae

KW - mitochondria

KW - mitochondrial division

KW - mitochondrial fusion

KW - phospholipid

KW - yeast

UR - https://www.scopus.com/pages/publications/85059809235

UR - https://www.scopus.com/pages/publications/85059809235#tab=citedBy

U2 - 10.1016/j.celrep.2018.12.070

DO - 10.1016/j.celrep.2018.12.070

M3 - Article

C2 - 30650346

AN - SCOPUS:85059809235

SN - 2639-1856

VL - 26

SP - 518-528.e6

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport

Abstract

Keywords

ASJC Scopus subject areas

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