Maintenance immunotherapy in ragweed hay fever. Booster injections at six week intervals

Philip S. Norman, Walter L. Winkenwerder, Lawrence M. Lichtenstein

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


In the immunotherapy of hay fever with pollen extracts, when treatment is temporarily discontinued after a course of weekly injections, the decline of blocking antibodies as measured by inhibition of leukocyte histamine release takes many months. The practice of giving booster injections in perennial immunotherapy every 2 or 3 weeks therefore appears unnecessary. To test this hypothesis, a schedule of perennial treatment with boosters at 6 week intervals was tried in a group of ragweed hay fever patients who had previously been treated with preseasonal injections for 2 or more years. Over two years, 8 injections a year (omitting an injection during the season) maintained and perhaps even augmented both clinical improvement and blocking antibody levels without problems caused by untoward reactions.

Original languageEnglish (US)
Pages (from-to)273-282
Number of pages10
JournalThe Journal of allergy and clinical immunology
Issue number5
StatePublished - May 1971
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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