Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine

Sandra V. Giannelli, Kushang V. Patel, B. Gwen Windham, Francesco Pizzarelli, Luigi Ferrucci, Jack M. Guralnik

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

OBJECTIVES: To estimate in a community-dwelling elderly population the magnitude of renal function misclassification, occurring when persons with normal serum creatinine have reduced glomerular filtration rate (GFR), and to describe the participant characteristics related to misclassification. DESIGN: Cross-sectional. SETTING: Population-based study of older Italian people. PARTICIPANTS: Six hundred sixty participants aged 65 to 92 with normal serum creatinine. MEASUREMENTS: GFR was estimated using the Cockcroft-Gault equation and creatinine clearance (CrCl) calculated from 24-hour urine collection. RESULTS: In participants with normal serum creatinine, 39% and 25% had moderate renal function impairment (GFR

Original languageEnglish (US)
Pages (from-to)816-823
Number of pages8
JournalJournal of the American Geriatrics Society
Volume55
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Creatinine
  • Elderly
  • GFR
  • Misclassification bias

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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