Magnetic targeting of magneto-plasmonic nanoparticles and their effects on temperature profile of nir laser irradiated to ct26 tumor in balb/c mice

Background: Photothermal therapy (PTT) is a promising method in the field of cancer hyperthermia. In this method, interaction between laser light and photosensi-tizer material, such as plasmonic nanoparticles, leads into a localized heating. Recent efforts in the area of PTT aim to exploit targeting strategies for preferential accumu-lation of plasmonic nanoparticles within the tumor. Objective: To investigate the impact of magneto-plasmonic (Au@Fe₂ O₃) nanoparticles on temperature profile of CT26 tumor, bearing mice were irradiated by NIR laser. Material and Methods: In this in vivo study, Au@Fe₂ O₃ NPs were injected intraperitoneally to Balb/c mice bearing CT26 colorectal tumor. Immediately after injection, a magnet (magnetic field strength of 0.4 Tesla) was placed on the tumor site for 6 hours in order to concentrate nanoparticles inside the tumor. In the next step, the tumors were exposed with NIR laser source (808 nm; 2 W/cm²; 5 min). Results: Tumor temperature without magnetic targeting increased ~7 ± 0.9 °C after NIR irradiation, whereas the tumors in magnetic targeted group experienced a temperature rise of ~12 ± 1.4 °C. Conclusion: It is concluded that Au@Fe₂ O₃ nanoparticle is a good candidate for therapeutic nanostructure in cancer photothermal therapy.