Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?

Argye E. Hillis; Paul Wang; Peter Barker; Norman Beauchamp; Barry Gordon; Robert Wityk

doi:10.1080/026870300401252

Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?

Argye E. Hillis, Paul Wang, Peter Barker, Norman Beauchamp, Barry Gordon, Robert Wityk

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We investigated correlations between lexical impairments and regional infarction versus hypoperfusion in hyperacute stroke (within 24 hours of onset). Seven patients with hyperacute dominant hemisphere stroke underwent a battery of lexical tasks, and investigational MRI techniques of Diffusion-Weighted Imaging (DWI) and Magnetic Resonance Perfusion Imaging (MRPI). Lexical performance was a function of regional hypoperfusion (on MRPI) rather than region of (probably) completed infarct (on DWI). Strong correlations were found between: accuracy in auditory word comprehension and volume of left temporal and parietal hypoperfusion, and accuracy of naming and left parietal hypoperfusion. Frequent errors in repetition were associated with left temporal and/or left frontal hypoperfusion, but the volume of infarct in these areas was not significantly correlated with the rate of repetition errors. Results of this preliminary study indicate that MRPI is a promising tool for investigating the regions of hypoperfused (dysfunctional, but not infarcted) brain tissue associated with specific language impairments in hyperacute stroke.

Original language	English (US)
Pages (from-to)	471-483
Number of pages	13
Journal	Aphasiology
Volume	14
Issue number	5-6
DOIs	https://doi.org/10.1080/026870300401252
State	Published - 2000

ASJC Scopus subject areas

Otorhinolaryngology
Language and Linguistics
Developmental and Educational Psychology
Linguistics and Language
Neurology
Clinical Neurology
LPN and LVN

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10.1080/026870300401252

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title = "Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?",

abstract = "We investigated correlations between lexical impairments and regional infarction versus hypoperfusion in hyperacute stroke (within 24 hours of onset). Seven patients with hyperacute dominant hemisphere stroke underwent a battery of lexical tasks, and investigational MRI techniques of Diffusion-Weighted Imaging (DWI) and Magnetic Resonance Perfusion Imaging (MRPI). Lexical performance was a function of regional hypoperfusion (on MRPI) rather than region of (probably) completed infarct (on DWI). Strong correlations were found between: accuracy in auditory word comprehension and volume of left temporal and parietal hypoperfusion, and accuracy of naming and left parietal hypoperfusion. Frequent errors in repetition were associated with left temporal and/or left frontal hypoperfusion, but the volume of infarct in these areas was not significantly correlated with the rate of repetition errors. Results of this preliminary study indicate that MRPI is a promising tool for investigating the regions of hypoperfused (dysfunctional, but not infarcted) brain tissue associated with specific language impairments in hyperacute stroke.",

author = "Hillis, {Argye E.} and Paul Wang and Peter Barker and Norman Beauchamp and Barry Gordon and Robert Wityk",

note = "Funding Information: The research reported in this paper was supported in part by K23, NS00174-01 from the NIDCD and by a Fellowship Award from the National Stroke Association, both to the first author. The authors are grateful to Dr Kevin Kearns, Dr Patrick Doyle, and two anonymous referees for their comments on an earlier version of this paper. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2000",

doi = "10.1080/026870300401252",

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AU - Wang, Paul

AU - Barker, Peter

AU - Beauchamp, Norman

AU - Gordon, Barry

AU - Wityk, Robert

N1 - Funding Information: The research reported in this paper was supported in part by K23, NS00174-01 from the NIDCD and by a Fellowship Award from the National Stroke Association, both to the first author. The authors are grateful to Dr Kevin Kearns, Dr Patrick Doyle, and two anonymous referees for their comments on an earlier version of this paper. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2000

Y1 - 2000

N2 - We investigated correlations between lexical impairments and regional infarction versus hypoperfusion in hyperacute stroke (within 24 hours of onset). Seven patients with hyperacute dominant hemisphere stroke underwent a battery of lexical tasks, and investigational MRI techniques of Diffusion-Weighted Imaging (DWI) and Magnetic Resonance Perfusion Imaging (MRPI). Lexical performance was a function of regional hypoperfusion (on MRPI) rather than region of (probably) completed infarct (on DWI). Strong correlations were found between: accuracy in auditory word comprehension and volume of left temporal and parietal hypoperfusion, and accuracy of naming and left parietal hypoperfusion. Frequent errors in repetition were associated with left temporal and/or left frontal hypoperfusion, but the volume of infarct in these areas was not significantly correlated with the rate of repetition errors. Results of this preliminary study indicate that MRPI is a promising tool for investigating the regions of hypoperfused (dysfunctional, but not infarcted) brain tissue associated with specific language impairments in hyperacute stroke.

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Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?

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