Magnetic resonance imaging reveals no ventriculomegaly in polydrug abusers

X. Liu, R. L. Phillips, S. M. Resnick, V. L. Villemagne, D. F. Wong, J. M. Stapleton, E. D. London

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Previous studies of cerebral structure in substance abusers yielded controversial results, largely due to issues of subject selection and/or limitations of experimental techniques. The purpose of the present study was to assess whether the ventricle‐to‐brain ratio (VBR), determined volumetrically by magnetic resonance imaging (MRI), differed in polysubstance abusers (n = 10), as compared with age‐matched controls (n = 10). Subjects were male volunteers 21–39 years of age. The values of VBR in the polydrug abuse group were not larger than those in control group, nor was there any tendency toward relative ventriculomegaly in the substance abusers. Therefore, the present findings provide no evidence that polysubstance abuse produces abnormalities of gross brain structure in relatively young and physically healthy men.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalActa Neurologica Scandinavica
Issue number1
StatePublished - Jul 1995
Externally publishedYes


  • MRI
  • drug abuse
  • lateral ventricles
  • method evaluation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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