TY - JOUR
T1 - Magnetic Resonance Imaging in Aneurysmal Subarachnoid Hemorrhage
T2 - Current Evidence and Future Directions
AU - Nelson, Sarah E.
AU - Sair, Haris I.
AU - Stevens, Robert D.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with an unacceptably high mortality and chronic disability in survivors, underscoring a need to validate new approaches for treatment and prognosis. The use of advanced imaging, magnetic resonance imaging (MRI) in particular, could help address this gap given its versatile capacity to quantitatively evaluate and map changes in brain anatomy, physiology and functional activation. Yet there is uncertainty about the real value of brain MRI in the clinical setting of aSAH. Methods: In this review, we discuss current and emerging MRI research in aSAH. PubMed was searched from inception to June 2017, and additional studies were then chosen on the basis of relevance to the topics covered in this review. Results: Available studies suggest that brain MRI is a feasible, safe, and valuable testing modality. MRI detects brain abnormalities associated with neurologic examination, outcomes, and aneurysm treatment and thus has the potential to increase knowledge of aSAH pathophysiology as well as to guide management and outcome prediction. Newer pulse sequences have the potential to reveal structural and physiological changes that could also improve management of aSAH. Conclusion: Research is needed to confirm the value of MRI-based biomarkers in clinical practice and as endpoints in clinical trials, with the goal of improving outcome for patients with aSAH.
AB - Background: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with an unacceptably high mortality and chronic disability in survivors, underscoring a need to validate new approaches for treatment and prognosis. The use of advanced imaging, magnetic resonance imaging (MRI) in particular, could help address this gap given its versatile capacity to quantitatively evaluate and map changes in brain anatomy, physiology and functional activation. Yet there is uncertainty about the real value of brain MRI in the clinical setting of aSAH. Methods: In this review, we discuss current and emerging MRI research in aSAH. PubMed was searched from inception to June 2017, and additional studies were then chosen on the basis of relevance to the topics covered in this review. Results: Available studies suggest that brain MRI is a feasible, safe, and valuable testing modality. MRI detects brain abnormalities associated with neurologic examination, outcomes, and aneurysm treatment and thus has the potential to increase knowledge of aSAH pathophysiology as well as to guide management and outcome prediction. Newer pulse sequences have the potential to reveal structural and physiological changes that could also improve management of aSAH. Conclusion: Research is needed to confirm the value of MRI-based biomarkers in clinical practice and as endpoints in clinical trials, with the goal of improving outcome for patients with aSAH.
KW - Magnetic resonance imaging
KW - Subarachnoid hemorrhage
KW - Systematic review
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U2 - 10.1007/s12028-018-0534-8
DO - 10.1007/s12028-018-0534-8
M3 - Article
C2 - 29633155
AN - SCOPUS:85045102623
SN - 1541-6933
VL - 29
SP - 241
EP - 252
JO - Neurocritical care
JF - Neurocritical care
IS - 2
ER -