Magnesium sulfate administration in subarachnoid hemorrhage

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Magnesium offers theoretic vascular and neuroprotective benefits for patients with subarachnoid hemorrhage. An electronic literature search was conducted to identify original research studies describing intravenous magnesium treatment in patients with SAH published in English between January 1990 and October 2010. Seventeen articles were identified and reviewed, including one phase III randomized-controlled clinical trial and six phase II randomized-controlled trials. Study quality was low for most of the included studies, with the phase III trial considered to be of moderate quality. Due to inconsistently reported benefits and the occurrence of side effects, phase II data suggested that intravenous magnesium for SAH provided either no overall net benefit or uncertain tradeoffs. Benefit was likewise not supported in the single phase III clinical trial.

Original languageEnglish (US)
Pages (from-to)302-307
Number of pages6
JournalNeurocritical care
Issue number2
StatePublished - Oct 2011
Externally publishedYes


  • Delayed cerebral ischemia
  • Infusion
  • Intravenous
  • Neuroprotection
  • Vasospasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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