Magnesium and blood pressure: Review of the epidemiologic and clinical trial experience

Paul K. Whelton, Michael J. Klag

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations


Observational and clinical trial experience suggest the possibility that magnesium may have both a physiologic and pharmacologic role in patients with essential hypertension. Unfortunately, the evidence from epidemiologic studies is inconsistent and many of the clinical trials are small and methodologically imperfect. In theory, magnesium supplementation could be used as a nonpharmacologic hypertensive agent in the individual patient with established hypertension or as a population-based treatment strategy aimed at achieving a slight downward shift in the entire distribution of blood pressure. Our current level of uncertainty is likely to persist until results from large, rigorously controlled observational and interventional studies become available.

Original languageEnglish (US)
Pages (from-to)G26-G30
JournalThe American journal of cardiology
Issue number14
StatePublished - Apr 18 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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