TY - JOUR
T1 - Macular degeneration
T2 - Recent advances and therapeutic opportunities
AU - Rattner, Amir
AU - Nathans, Jeremy
N1 - Funding Information:
The authors thank the following colleagues for permission to reproduce images: R. Cucu (BOX 1c); G. Hageman (FIG. 5a–c); F. Holz (BOX 1b); L. Johnson (FIG. 5d); R. Lewis (FIG. 2a,c); J. Sparrow (FIG. 3b); E. Stone (FIG. 2b; BOX 1a); and H. Sun (FIG. 4a). The authors are supported by the National Institutes of Health (National Eye Institute) and the Howard Hughes Medical Institute.
PY - 2006/11
Y1 - 2006/11
N2 - The central retina mediates high acuity vision, and its progressive dysfunction due to macular degeneration is the leading cause of visual disability among adults in industrialized societies. Here, we summarize recent progress in understanding the pathophysiology of macular degeneration and the implications of this new knowledge for treatment and prevention. The past decade has witnessed remarkable advances in this field, including the development of new, non-invasive retinal imaging technologies, the development of animal models for macular disease, and the isolation of many of the genes responsible for both early- and late-onset macular diseases. These advances have set the stage for the development of effective mechanism-based therapies.
AB - The central retina mediates high acuity vision, and its progressive dysfunction due to macular degeneration is the leading cause of visual disability among adults in industrialized societies. Here, we summarize recent progress in understanding the pathophysiology of macular degeneration and the implications of this new knowledge for treatment and prevention. The past decade has witnessed remarkable advances in this field, including the development of new, non-invasive retinal imaging technologies, the development of animal models for macular disease, and the isolation of many of the genes responsible for both early- and late-onset macular diseases. These advances have set the stage for the development of effective mechanism-based therapies.
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U2 - 10.1038/nrn2007
DO - 10.1038/nrn2007
M3 - Review article
C2 - 17033682
AN - SCOPUS:33750300224
SN - 1471-003X
VL - 7
SP - 860
EP - 872
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 11
ER -