Macrocystic serous cystadenoma of the pancreas: A morphologic variant differing from microcystic adenoma

Kent Lewandrowski, Andrew Warshaw, Carolyn Compton

Research output: Contribution to journalArticlepeer-review

152 Scopus citations


The term "microcystic adenoma" of the pancreas has gained nearly universal acceptance among pathologists owing to the characteristic gross and microscopic features of this tumor. The possible existence of macrocystic variants of serous cystadenoma has been largely ignored in the literature. We report five cases of macrocystic serous cystadenoma of the pancreas, two of which were of the unilocular type. These tumors exhibited distinctly different macroscopic features from microcystic adenoma, which created diagnostic difficulties for both the radiologist and pathologist. Computed tomography scans on all five cases were thought to represent either mucinous cystic neoplasms or pseudocysts and the tumors were misclassified in two of three cases on which intraoperative frozen sections were performed. In our opinion, microcystic and macrocystic serous tumors represent morphologic variants of the same benign pancreatic neoplasm and we suggest that the term "serous cystadenoma" be used to encompass all variants of this benign neoplasm.

Original languageEnglish (US)
Pages (from-to)871-875
Number of pages5
JournalHuman Pathology
Issue number8
StatePublished - 1992
Externally publishedYes


  • glycogen-rich adenoma
  • microcystic adenoma
  • pancreas tumors
  • serous cystadenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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