Lymphohematopoiesis: Role of growth factors in leukemogenesis and therapy

M. J. Fackler, L. C. Strauss

Research output: Contribution to journalReview articlepeer-review


The interrelationship between proliferation, differentiation, and activation responses of hematopoietic progenitor cells and mature blood cells is complex. Therefore, we are only now learning what role colony-stimulating factors play in the regulation of normal hematopoiesis in vivo and in the dysregulation of hematopoiesis in leukemia. Recent advantages in molecular hematology have opened the door to the therapeutic adminstration of recombinant growth factors. Through continued preclinical trials in animals and by clinical trials in humans, a better understanding of the precise target cells and mechanisms of action of hematopoietic growth factors will improve the therapeutic index of administering colony-stimulating factors. Better understanding of hematopoietic growth factors will, in turn, suggest novel approaches to therapy of acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)849-865
Number of pages17
JournalHematology/Oncology Clinics of North America
Issue number4
StatePublished - 1990

ASJC Scopus subject areas

  • Hematology
  • Oncology


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