TY - JOUR
T1 - Lymphocytic Thrombophilic Arteritis
T2 - A Review
AU - Vakili, Sharif
AU - Zampella, John G.
AU - Kwatra, Shawn
AU - Blanck, Jaime
AU - Loss, Manisha
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Macular lymphocytic arteritis or lymphocytic thrombophilic arteritis (LTA) is a recently described cutaneous arteritis that is characterized by asymptomatic macules and patches of the extremities associated with lymphocytic arteritis at the deep dermal/subcuticular junction for which little information exists on demographics, evaluation, and management. There has been recent debate in the literature whether this disease is a new distinct entity, misdiagnosed cutaneous polyarteritis nodosa (cPAN), or a disease on a spectrum with cPAN. We systematically review the literature on demographic information, medical history, histopathology findings, and treatment management to analyze trends and clarify controversies in characterizations of LTA. Forty detailed cases of LTA have been published. We submit that, although literature is limited, a review of the data still suggests that LTA is distinct from cPAN and systemic PAN. In addition, to better reflect the pathophysiologic natural history of this condition and correct for the historical artifact of how the disease was identified, we encourage the disease to be referred to as LTA and discourage ongoing use of macular lymphocytic arteritis.
AB - Macular lymphocytic arteritis or lymphocytic thrombophilic arteritis (LTA) is a recently described cutaneous arteritis that is characterized by asymptomatic macules and patches of the extremities associated with lymphocytic arteritis at the deep dermal/subcuticular junction for which little information exists on demographics, evaluation, and management. There has been recent debate in the literature whether this disease is a new distinct entity, misdiagnosed cutaneous polyarteritis nodosa (cPAN), or a disease on a spectrum with cPAN. We systematically review the literature on demographic information, medical history, histopathology findings, and treatment management to analyze trends and clarify controversies in characterizations of LTA. Forty detailed cases of LTA have been published. We submit that, although literature is limited, a review of the data still suggests that LTA is distinct from cPAN and systemic PAN. In addition, to better reflect the pathophysiologic natural history of this condition and correct for the historical artifact of how the disease was identified, we encourage the disease to be referred to as LTA and discourage ongoing use of macular lymphocytic arteritis.
KW - diagnosis
KW - lymphocytic thrombophilic arteritis
KW - macular lymphocytic arteritis
KW - management
KW - polyarteritis nodosa
KW - review
KW - vasculitis
UR - http://www.scopus.com/inward/record.url?scp=85063803121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063803121&partnerID=8YFLogxK
U2 - 10.1097/RHU.0000000000000846
DO - 10.1097/RHU.0000000000000846
M3 - Review article
C2 - 30044260
AN - SCOPUS:85063803121
SN - 1076-1608
VL - 25
SP - 147
EP - 152
JO - Journal of Clinical Rheumatology
JF - Journal of Clinical Rheumatology
IS - 3
ER -