Lymphocyte calcium signaling from membrane to nucleus

Elena M. Gallo, Kirsten Canté-Barrett, Gerald R. Crabtree

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+ -dependent transcription regulates lymphocyte function.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalNature Immunology
Issue number1
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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