Lymphatic Mapping and Sentinel Node Biopsy in High-Grade Uterine Cancers

Jeffrey A. How; Michael Frumovitz; Katherine I. Stewart; Pamela T. Soliman

doi:10.1007/s11912-022-01294-0

Lymphatic Mapping and Sentinel Node Biopsy in High-Grade Uterine Cancers

Jeffrey A. How, Michael Frumovitz, Katherine I. Stewart, Pamela T. Soliman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: Sentinel lymph node (SLN) mapping has been adopted as an acceptable method of lymph node evaluation in the surgical staging for low-grade endometrial cancer. In this review, we analyze the literature on the utility of SLN mapping in high-grade endometrial cancer. Recent Findings: SLN mapping in high-grade endometrial cancer demonstrates similar high detection rates and diagnostic accuracy as seen in low-grade endometrial cancers. However, obtaining sufficient operator experience (at least 30 cases) and following SLN mapping algorithm continues to be essential to preserving diagnostic accuracy. Although limited in retrospective study design and short-term follow-up, current studies have not demonstrated inferior survival outcomes of SLN mapping compared to traditional lymphadenectomy. Summary: SLN mapping is an acceptable and accurate method of lymph node evaluation in high-grade endometrial cancer. Future prospective studies are needed to evaluate long-term oncologic outcomes between SLN mapping and systematic lymphadenectomy in this patient population.

Original language	English (US)
Pages (from-to)	1521-1529
Number of pages	9
Journal	Current oncology reports
Volume	24
Issue number	11
DOIs	https://doi.org/10.1007/s11912-022-01294-0
State	Published - Nov 2022

Keywords

Diagnostic accuracy
Endometrial cancer
High grade
Lymph node
Sentinel lymph node mapping
Surgical staging

ASJC Scopus subject areas

Oncology

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10.1007/s11912-022-01294-0

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title = "Lymphatic Mapping and Sentinel Node Biopsy in High-Grade Uterine Cancers",

abstract = "Purpose of Review: Sentinel lymph node (SLN) mapping has been adopted as an acceptable method of lymph node evaluation in the surgical staging for low-grade endometrial cancer. In this review, we analyze the literature on the utility of SLN mapping in high-grade endometrial cancer. Recent Findings: SLN mapping in high-grade endometrial cancer demonstrates similar high detection rates and diagnostic accuracy as seen in low-grade endometrial cancers. However, obtaining sufficient operator experience (at least 30 cases) and following SLN mapping algorithm continues to be essential to preserving diagnostic accuracy. Although limited in retrospective study design and short-term follow-up, current studies have not demonstrated inferior survival outcomes of SLN mapping compared to traditional lymphadenectomy. Summary: SLN mapping is an acceptable and accurate method of lymph node evaluation in high-grade endometrial cancer. Future prospective studies are needed to evaluate long-term oncologic outcomes between SLN mapping and systematic lymphadenectomy in this patient population.",

keywords = "Diagnostic accuracy, Endometrial cancer, High grade, Lymph node, Sentinel lymph node mapping, Surgical staging",

author = "How, {Jeffrey A.} and Michael Frumovitz and Stewart, {Katherine I.} and Soliman, {Pamela T.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = nov,

doi = "10.1007/s11912-022-01294-0",

language = "English (US)",

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AU - How, Jeffrey A.

AU - Frumovitz, Michael

AU - Stewart, Katherine I.

AU - Soliman, Pamela T.

PY - 2022/11

Y1 - 2022/11

N2 - Purpose of Review: Sentinel lymph node (SLN) mapping has been adopted as an acceptable method of lymph node evaluation in the surgical staging for low-grade endometrial cancer. In this review, we analyze the literature on the utility of SLN mapping in high-grade endometrial cancer. Recent Findings: SLN mapping in high-grade endometrial cancer demonstrates similar high detection rates and diagnostic accuracy as seen in low-grade endometrial cancers. However, obtaining sufficient operator experience (at least 30 cases) and following SLN mapping algorithm continues to be essential to preserving diagnostic accuracy. Although limited in retrospective study design and short-term follow-up, current studies have not demonstrated inferior survival outcomes of SLN mapping compared to traditional lymphadenectomy. Summary: SLN mapping is an acceptable and accurate method of lymph node evaluation in high-grade endometrial cancer. Future prospective studies are needed to evaluate long-term oncologic outcomes between SLN mapping and systematic lymphadenectomy in this patient population.

AB - Purpose of Review: Sentinel lymph node (SLN) mapping has been adopted as an acceptable method of lymph node evaluation in the surgical staging for low-grade endometrial cancer. In this review, we analyze the literature on the utility of SLN mapping in high-grade endometrial cancer. Recent Findings: SLN mapping in high-grade endometrial cancer demonstrates similar high detection rates and diagnostic accuracy as seen in low-grade endometrial cancers. However, obtaining sufficient operator experience (at least 30 cases) and following SLN mapping algorithm continues to be essential to preserving diagnostic accuracy. Although limited in retrospective study design and short-term follow-up, current studies have not demonstrated inferior survival outcomes of SLN mapping compared to traditional lymphadenectomy. Summary: SLN mapping is an acceptable and accurate method of lymph node evaluation in high-grade endometrial cancer. Future prospective studies are needed to evaluate long-term oncologic outcomes between SLN mapping and systematic lymphadenectomy in this patient population.

KW - Diagnostic accuracy

KW - Endometrial cancer

KW - High grade

KW - Lymph node

KW - Sentinel lymph node mapping

KW - Surgical staging

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JO - Current oncology reports

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Lymphatic Mapping and Sentinel Node Biopsy in High-Grade Uterine Cancers

Abstract

Keywords

ASJC Scopus subject areas

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