Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure: A pilot sampler study in stainless steel welders

Ashley Newton; Berrin Serdar; Karin Adams; L. Miriam Dickinson; Kirsten Koehler

doi:10.1016/j.jaerosci.2020.105721

Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure: A pilot sampler study in stainless steel welders

Ashley Newton, Berrin Serdar, Karin Adams, L. Miriam Dickinson, Kirsten Koehler

Research output: Contribution to journal › Article › peer-review

Abstract

This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed for inhalable and lung-deposited nickel and chromium and urine was analyzed for the respective biomarkers of internal dose. There were statistically significant relationships between lung-deposited nickel (β_Ni = 0.10; 95% CI = 0.05–0.16) and chromium (β_Cr = 0.07; 95% CI = 0.006–0.14) and their internal dose biomarkers. No relationship was found between inhalable metals and internal dose biomarkers. In moving towards a more physiologically relevant exposure metric, the LDS can provide better estimates for the total body burden of exposure than traditional penetration-based samplers.

Original language	English (US)
Article number	105721
Journal	Journal of Aerosol Science
Volume	153
DOIs	https://doi.org/10.1016/j.jaerosci.2020.105721
State	Published - Mar 2021
Externally published	Yes

Keywords

Lung deposition
Sampler validation
Welding aerosols

ASJC Scopus subject areas

Environmental Engineering
Pollution
Mechanical Engineering
Fluid Flow and Transfer Processes
Atmospheric Science

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10.1016/j.jaerosci.2020.105721

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@article{cc08fffe978249f0b84f32a5c057b9eb,

title = "Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure: A pilot sampler study in stainless steel welders",

abstract = "This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed for inhalable and lung-deposited nickel and chromium and urine was analyzed for the respective biomarkers of internal dose. There were statistically significant relationships between lung-deposited nickel (βNi = 0.10; 95% CI = 0.05–0.16) and chromium (βCr = 0.07; 95% CI = 0.006–0.14) and their internal dose biomarkers. No relationship was found between inhalable metals and internal dose biomarkers. In moving towards a more physiologically relevant exposure metric, the LDS can provide better estimates for the total body burden of exposure than traditional penetration-based samplers.",

keywords = "Lung deposition, Sampler validation, Welding aerosols",

author = "Ashley Newton and Berrin Serdar and Karin Adams and Dickinson, {L. Miriam} and Kirsten Koehler",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = mar,

doi = "10.1016/j.jaerosci.2020.105721",

language = "English (US)",

volume = "153",

journal = "Journal of Aerosol Science",

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T1 - Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure

T2 - A pilot sampler study in stainless steel welders

AU - Newton, Ashley

AU - Serdar, Berrin

AU - Adams, Karin

AU - Dickinson, L. Miriam

AU - Koehler, Kirsten

PY - 2021/3

Y1 - 2021/3

N2 - This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed for inhalable and lung-deposited nickel and chromium and urine was analyzed for the respective biomarkers of internal dose. There were statistically significant relationships between lung-deposited nickel (βNi = 0.10; 95% CI = 0.05–0.16) and chromium (βCr = 0.07; 95% CI = 0.006–0.14) and their internal dose biomarkers. No relationship was found between inhalable metals and internal dose biomarkers. In moving towards a more physiologically relevant exposure metric, the LDS can provide better estimates for the total body burden of exposure than traditional penetration-based samplers.

AB - This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed for inhalable and lung-deposited nickel and chromium and urine was analyzed for the respective biomarkers of internal dose. There were statistically significant relationships between lung-deposited nickel (βNi = 0.10; 95% CI = 0.05–0.16) and chromium (βCr = 0.07; 95% CI = 0.006–0.14) and their internal dose biomarkers. No relationship was found between inhalable metals and internal dose biomarkers. In moving towards a more physiologically relevant exposure metric, the LDS can provide better estimates for the total body burden of exposure than traditional penetration-based samplers.

KW - Lung deposition

KW - Sampler validation

KW - Welding aerosols

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VL - 153

JO - Journal of Aerosol Science

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ER -

Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure: A pilot sampler study in stainless steel welders

Abstract

Keywords

ASJC Scopus subject areas

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