Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity

Marta Stasiak; Joanna Boncela; Corinne Perreau; Konstantina Karamanou; Aurore Chatron-Colliet; Isabelle Proult; Patrycja Przygodzka; Shukti Chakravarti; François Xavier Maquart; M. Anna Kowalska; Yanusz Wegrowski; Stéphane Brézillon

doi:10.1371/journal.pone.0150226

Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity

Marta Stasiak, Joanna Boncela, Corinne Perreau, Konstantina Karamanou, Aurore Chatron-Colliet, Isabelle Proult, Patrycja Przygodzka, Shukti Chakravarti, François Xavier Maquart, M. Anna Kowalska, Yanusz Wegrowski, Stéphane Brézillon

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

Original language	English (US)
Article number	e0150226
Journal	PLoS One
Volume	11
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0150226
State	Published - Mar 1 2016

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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title = "Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity",

abstract = "Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.",

author = "Marta Stasiak and Joanna Boncela and Corinne Perreau and Konstantina Karamanou and Aurore Chatron-Colliet and Isabelle Proult and Patrycja Przygodzka and Shukti Chakravarti and Maquart, {Fran{\c c}ois Xavier} and Kowalska, {M. Anna} and Yanusz Wegrowski and St{\'e}phane Br{\'e}zillon",

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AU - Boncela, Joanna

AU - Perreau, Corinne

AU - Karamanou, Konstantina

AU - Chatron-Colliet, Aurore

AU - Proult, Isabelle

AU - Przygodzka, Patrycja

AU - Chakravarti, Shukti

AU - Maquart, François Xavier

AU - Kowalska, M. Anna

AU - Wegrowski, Yanusz

AU - Brézillon, Stéphane

PY - 2016/3/1

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AB - Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

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Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity

Abstract

ASJC Scopus subject areas

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