LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTPase activity of LRRK2 seem to be important in regulating LRRK2-dependent cellular signalling pathways. LRRK2's GTPase and kinase domains may reciprocally regulate each other to direct LRRK2's ultimate function. Although most LRRK2 investigations are centred on LRRK2's kinase activity, the present review focuses on the function of LRRK2's GTPase activity in LRRK2 physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)1074-1079
Number of pages6
JournalBiochemical Society transactions
Issue number5
StatePublished - Oct 2012


  • GTPase
  • GTPase-activating protein (GAP)
  • Guanine-nucleotide-exchange factor (GEF)
  • Kinase
  • Leucine-rich repeat kinase 2 (LRRK2)
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry


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