Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

Lauren M. Osborne; Fiona Gispen; Abanti Sanyal; Gayane Yenokyan; Samantha Meilman; Jennifer L. Payne

doi:10.1016/j.psyneuen.2017.02.012

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

Lauren M. Osborne, Fiona Gispen, Abanti Sanyal, Gayane Yenokyan, Samantha Meilman, Jennifer L. Payne

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p = 0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

Original language	English (US)
Pages (from-to)	116-121
Number of pages	6
Journal	Psychoneuroendocrinology
Volume	79
DOIs	https://doi.org/10.1016/j.psyneuen.2017.02.012
State	Published - May 1 2017

Keywords

Anxiety
Depression
Hormones
Postpartum
Pregnancy
Reproductive

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psyneuen.2017.02.012

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title = "Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study",

abstract = "Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p = 0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.",

keywords = "Anxiety, Depression, Hormones, Postpartum, Pregnancy, Reproductive",

author = "Osborne, {Lauren M.} and Fiona Gispen and Abanti Sanyal and Gayane Yenokyan and Samantha Meilman and Payne, {Jennifer L.}",

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doi = "10.1016/j.psyneuen.2017.02.012",

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T1 - Lower allopregnanolone during pregnancy predicts postpartum depression

T2 - An exploratory study

AU - Osborne, Lauren M.

AU - Gispen, Fiona

AU - Sanyal, Abanti

AU - Yenokyan, Gayane

AU - Meilman, Samantha

AU - Payne, Jennifer L.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p = 0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

AB - Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p = 0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

KW - Anxiety

KW - Depression

KW - Hormones

KW - Postpartum

KW - Pregnancy

KW - Reproductive

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ER -

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

Abstract

Keywords

ASJC Scopus subject areas

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