TY - JOUR
T1 - Low serum selenium and total carotenoids predict mortality among older women living in the community
T2 - The Women's Health and Aging Studies
AU - Ray, Amanda L.
AU - Semba, Richard D.
AU - Walston, Jeremy
AU - Ferrucci, Luigi
AU - Cappola, Anne R.
AU - Ricks, Michelle O.
AU - Xue, Qian Li
AU - Fried, Linda P.
PY - 2006/1
Y1 - 2006/1
N2 - Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and II in Baltimore, MD (n = 632; 70-79 y old) had serum selenium and carotenoids measured at baseline and were followed for mortality over 60 mo. Median (minimum, maximum) serum selenium and carotenoids were 1.53 (0.73, 2.51) μmol/L and 1.67 (0.13, 9.10) μmol/L; 14.1% of the women died. The 5 major causes of death were heart disease (32.6%), cancer (18.0%), stroke (9.0%), infection (6.7%), and chronic obstructive pulmonary disease (5.6%). Adjusting for age, education, smoking, BMI, poor appetite, and chronic diseases, higher serum selenium [hazard ratio (HR) 0.71, 95% CI 0.56-0.90/1 SD increase in loge selenium; P = 0.005] and higher serum total carotenoids (HR 0.77, 95% CI 0.64-0.84/1 SD increase in loge total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death.
AB - Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and II in Baltimore, MD (n = 632; 70-79 y old) had serum selenium and carotenoids measured at baseline and were followed for mortality over 60 mo. Median (minimum, maximum) serum selenium and carotenoids were 1.53 (0.73, 2.51) μmol/L and 1.67 (0.13, 9.10) μmol/L; 14.1% of the women died. The 5 major causes of death were heart disease (32.6%), cancer (18.0%), stroke (9.0%), infection (6.7%), and chronic obstructive pulmonary disease (5.6%). Adjusting for age, education, smoking, BMI, poor appetite, and chronic diseases, higher serum selenium [hazard ratio (HR) 0.71, 95% CI 0.56-0.90/1 SD increase in loge selenium; P = 0.005] and higher serum total carotenoids (HR 0.77, 95% CI 0.64-0.84/1 SD increase in loge total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death.
KW - Aging
KW - Carotenoids
KW - Mortality
KW - Selenium
KW - Women
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U2 - 10.1093/jn/136.1.172
DO - 10.1093/jn/136.1.172
M3 - Article
C2 - 16365078
AN - SCOPUS:31544452253
SN - 0022-3166
VL - 136
SP - 172
EP - 176
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 1
ER -