TY - JOUR
T1 - Low plasma selenium concentrations and mortality among older community-dwelling adults
T2 - The InCHIANTI study
AU - Lauretani, Fulvio
AU - Semba, Richard D.
AU - Bandinelli, Stcfania
AU - Ray, Amanda L.
AU - Ruggiero, Carmelinda
AU - Cherubini, Antonio
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
N1 - Funding Information:
This work was supported by National Institute on Aging Contracts N01-AG-916413, N01-AG-821336, N01-AG-5-0002 and NIA Grant R01 AG027012. This research was partly supported by the Intramural Research Program, National Institute on Aging, NIH. Sponsors’ Role: None.
PY - 2008/4
Y1 - 2008/4
N2 - Aims: We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study. Methods: 1042 men and women ≥65 years from the InCHIANTI study, a population-based study of older adults living in the Chianti tegion of Tuscany, a population-based cohort in Tuscany, Italy. Plasma selenium was measured at enrollment (1998-2000), and vital status was ascertained until May 2006. Results: During follow-up, 237 participants (22.7%) died. At enrollment, mean (SD) plasma selenium concentrations among participants who survived or died were 0.96 (0.14) and 0.87 (0.18) μmol/L (p<0.0001), respectively. The proportion of participants who died, from lowest to highest quartile of selenium, was 41.3, 27.0, 18.1 and 13.5% (p<0.0001 by Mantel-Haenszel chi-square). After adjusting for age, sex, education, and chronic diseases, adults in the lowest quartile of plasma selenium at enrollment had higher mortality compared with those in the highest quartile (Hazard Ratio (HR) 1.60, 95% Confidence Interval (CI) 1.04-2.47, p=0.034). Conclusion: Low plasma selenium may be an independent predictor of mortality among older adults living in the community.
AB - Aims: We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study. Methods: 1042 men and women ≥65 years from the InCHIANTI study, a population-based study of older adults living in the Chianti tegion of Tuscany, a population-based cohort in Tuscany, Italy. Plasma selenium was measured at enrollment (1998-2000), and vital status was ascertained until May 2006. Results: During follow-up, 237 participants (22.7%) died. At enrollment, mean (SD) plasma selenium concentrations among participants who survived or died were 0.96 (0.14) and 0.87 (0.18) μmol/L (p<0.0001), respectively. The proportion of participants who died, from lowest to highest quartile of selenium, was 41.3, 27.0, 18.1 and 13.5% (p<0.0001 by Mantel-Haenszel chi-square). After adjusting for age, sex, education, and chronic diseases, adults in the lowest quartile of plasma selenium at enrollment had higher mortality compared with those in the highest quartile (Hazard Ratio (HR) 1.60, 95% Confidence Interval (CI) 1.04-2.47, p=0.034). Conclusion: Low plasma selenium may be an independent predictor of mortality among older adults living in the community.
KW - Aging
KW - Mortality
KW - Selenium
UR - http://www.scopus.com/inward/record.url?scp=44449100704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449100704&partnerID=8YFLogxK
U2 - 10.1007/BF03324762
DO - 10.1007/BF03324762
M3 - Article
C2 - 18431083
AN - SCOPUS:44449100704
SN - 1594-0667
VL - 20
SP - 153
EP - 158
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 2
ER -