TY - JOUR
T1 - Low-level inorganic arsenic exposure and neuropsychological functioning in American Indian elders
AU - Carroll, Clint R.
AU - Noonan, Carolyn
AU - Garroutte, Eva M.
AU - Navas-Acien, Ana
AU - Verney, Steven P.
AU - Buchwald, Dedra
N1 - Funding Information:
This study was supported by research grants (R01 HL090863, R01 HL093086, R01 HL109282, R01 HL109284, R01 HL109301, R01 HL109315, and R01 HL109319) and cooperative agreement grants (U01 HL41642, U01 HL41652, U01 HL41654, U01 HL65520, and U01 HL65521) from the National Heart, Lung, and Blood Institute, and a grant from the National Institute of Environmental Health Sciences (R01 ES021367). The preparation of the manuscript was supported in part by the National Institute on Aging (P30 AG15292; S.M. Manson, PI) through the Native Elder Research Center, which is jointly administered by the University of Washington and the University of Colorado Denver. Dr. Carroll was supported in part by a Ford Foundation Post-Doctoral Fellowship administered by the National Academy of Sciences. The authors would like to thank all Strong Heart Study and Cerebrovascular Disease and its Consequences in American Indians study participants, staff, and investigators, as well as the Native Elder Research Center faculty, trainees, and staff for their help in refining this article to its present form. The authors also thank Raymond M. Harris, Ph.D., for editing assistance.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017
Y1 - 2017
N2 - Background Inorganic arsenic at high and prolonged doses is highly neurotoxic. Few studies have evaluated whether long-term, low-level arsenic exposure is associated with neuropsychological functioning in adults. Objectives To investigate the association between long-term, low-level inorganic arsenic exposure and neuropsychological functioning among American Indians aged 64–95. Methods We assessed 928 participants in the Strong Heart Study by using data on arsenic species in urine samples collected at baseline (1989–1991) and results of standardized tests of global cognition, executive functioning, verbal learning and memory, fine motor functioning, and speed of mental processing administered during comprehensive follow-up evaluations in 2009–2013. We calculated the difference in neuropsychological functioning for a 10% increase in urinary arsenic with adjustment for sex, age, education, and study site. Results The sum of inorganic and methylated arsenic species (∑As) in urine was associated with limited fine motor functioning and processing speed. A 10% increase in ∑As was associated with a.10 (95% CI −.20, −.01) decrease on the Finger Tapping Test for the dominant hand and a.13 decrease (95% CI −.21, −.04) for the non-dominant hand. Similarly, a 10% increase in ∑As was associated with a.15 (95% CI −.29,.00) decrease on the Wechsler Adult Intelligence Scale–Fourth Edition Coding Subtest. ∑As was not associated with other neuropsychological functions. Conclusions Findings indicate an adverse association between increased urinary arsenic fine motor functioning and processing speed, but not with other neuropsychological functioning, among elderly American Indians.
AB - Background Inorganic arsenic at high and prolonged doses is highly neurotoxic. Few studies have evaluated whether long-term, low-level arsenic exposure is associated with neuropsychological functioning in adults. Objectives To investigate the association between long-term, low-level inorganic arsenic exposure and neuropsychological functioning among American Indians aged 64–95. Methods We assessed 928 participants in the Strong Heart Study by using data on arsenic species in urine samples collected at baseline (1989–1991) and results of standardized tests of global cognition, executive functioning, verbal learning and memory, fine motor functioning, and speed of mental processing administered during comprehensive follow-up evaluations in 2009–2013. We calculated the difference in neuropsychological functioning for a 10% increase in urinary arsenic with adjustment for sex, age, education, and study site. Results The sum of inorganic and methylated arsenic species (∑As) in urine was associated with limited fine motor functioning and processing speed. A 10% increase in ∑As was associated with a.10 (95% CI −.20, −.01) decrease on the Finger Tapping Test for the dominant hand and a.13 decrease (95% CI −.21, −.04) for the non-dominant hand. Similarly, a 10% increase in ∑As was associated with a.15 (95% CI −.29,.00) decrease on the Wechsler Adult Intelligence Scale–Fourth Edition Coding Subtest. ∑As was not associated with other neuropsychological functions. Conclusions Findings indicate an adverse association between increased urinary arsenic fine motor functioning and processing speed, but not with other neuropsychological functioning, among elderly American Indians.
KW - American Indians
KW - Arsenic
KW - Low-level exposure
KW - Neuropsychological functioning
KW - Strong Heart Study
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U2 - 10.1016/j.envres.2017.03.018
DO - 10.1016/j.envres.2017.03.018
M3 - Article
C2 - 28334644
AN - SCOPUS:85015432197
SN - 0013-9351
VL - 156
SP - 74
EP - 79
JO - Environmental research
JF - Environmental research
ER -