Low-Intensity Pulsed Ultrasound as a Potential Adjuvant Therapy to Promote Spinal Fusion

Ethan Cottrill; Max Downey; Zach Pennington; Jeff Ehresman; Andrew Schilling; Madison Downey; Andrew Hersh; Nicholas Theodore; Daniel M. Sciubba; Timothy Witham

doi:10.1002/jum.15587

Low-Intensity Pulsed Ultrasound as a Potential Adjuvant Therapy to Promote Spinal Fusion

Ethan Cottrill, Max Downey, Zach Pennington, Jeff Ehresman, Andrew Schilling, Madison Downey, Andrew Hersh, Nicholas Theodore, Daniel M. Sciubba, Timothy Witham

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite extensive research, nonunion continues to affect a nontrivial proportion of patients undergoing spinal fusion. Recently, preclinical studies have suggested that low-intensity pulsed ultrasound (LIPUS) may increase rates of spinal fusion. In this study, we summarized the available in vivo literature evaluating the effect of LIPUS on spinal fusion and performed a meta-analysis of the available data to estimate the degree to which LIPUS may mediate higher fusion rates. Across 13 preclinical studies, LIPUS was associated with a 9-fold increase in the odds of successful spinal fusion. Future studies are necessary to establish the benefit of LIPUS on spinal fusion in clinical populations.

Original language	English (US)
Pages (from-to)	2005-2017
Number of pages	13
Journal	Journal of Ultrasound in Medicine
Volume	40
Issue number	10
DOIs	https://doi.org/10.1002/jum.15587
State	Published - Oct 2021

Keywords

low-intensity pulsed ultrasound
nonunion
pseudarthrosis
spinal fusion

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1002/jum.15587

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abstract = "Despite extensive research, nonunion continues to affect a nontrivial proportion of patients undergoing spinal fusion. Recently, preclinical studies have suggested that low-intensity pulsed ultrasound (LIPUS) may increase rates of spinal fusion. In this study, we summarized the available in vivo literature evaluating the effect of LIPUS on spinal fusion and performed a meta-analysis of the available data to estimate the degree to which LIPUS may mediate higher fusion rates. Across 13 preclinical studies, LIPUS was associated with a 9-fold increase in the odds of successful spinal fusion. Future studies are necessary to establish the benefit of LIPUS on spinal fusion in clinical populations.",

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AU - Cottrill, Ethan

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AU - Pennington, Zach

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AU - Schilling, Andrew

AU - Downey, Madison

AU - Hersh, Andrew

AU - Theodore, Nicholas

AU - Sciubba, Daniel M.

AU - Witham, Timothy

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AB - Despite extensive research, nonunion continues to affect a nontrivial proportion of patients undergoing spinal fusion. Recently, preclinical studies have suggested that low-intensity pulsed ultrasound (LIPUS) may increase rates of spinal fusion. In this study, we summarized the available in vivo literature evaluating the effect of LIPUS on spinal fusion and performed a meta-analysis of the available data to estimate the degree to which LIPUS may mediate higher fusion rates. Across 13 preclinical studies, LIPUS was associated with a 9-fold increase in the odds of successful spinal fusion. Future studies are necessary to establish the benefit of LIPUS on spinal fusion in clinical populations.

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Low-Intensity Pulsed Ultrasound as a Potential Adjuvant Therapy to Promote Spinal Fusion

Abstract

Keywords

ASJC Scopus subject areas

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