Abstract
We report the low incidence of hepatic VOD in pediatric patients with various diagnoses including hematologic malignancies and non-malignant conditions transplanted at our institution. Retrospective review of 188 patients who underwent HSCT and received a combined prophylactic regimen of intravenous heparin, oral glutamine, and ursodiol was undertaken. Analysis of the outcome of VOD revealed only one clinical case with acute myeloid leukemia; the patient developed hepatic VOD 10 days after receiving myeloablative chemotherapy with busulfan and CTX followed by HLA-matched related peripheral blood stem cell transplantation. The low incidence of hepatic VOD in an otherwise high-risk pediatric transplant population is an important observation, which may be partly attributed to this prophylactic regimen, and warrants further randomized clinical trials for confirmation.
Original language | English (US) |
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Pages (from-to) | 618-621 |
Number of pages | 4 |
Journal | Pediatric transplantation |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2010 |
Externally published | Yes |
Keywords
- glutamine
- heparin
- ursodiol
- veno-occlusive disease
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation