TY - JOUR
T1 - Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry
T2 - A prospective study
AU - Marete, Irene
AU - Tenge, Constance
AU - Chemweno, Carolyne
AU - Bucher, Sherri
AU - Pasha, Omrana
AU - Ramadurg, Umesh Y.
AU - Mastiholi, Shivanand C.
AU - Chiwila, Melody
AU - Patel, Archana
AU - Althabe, Fernando
AU - Garces, Ana
AU - Moore, Janet L.
AU - Liechty, Edward A.
AU - Derman, Richard J.
AU - Hibberd, Patricia L.
AU - Hambidge, K. Michael
AU - Goldenberg, Robert L.
AU - Carlo, Waldemar A.
AU - Koso-Thomas, Marion
AU - McClure, Elizabeth M.
AU - Esamai, Fabian
N1 - Funding Information:
We acknowledge the work of all the Registry Administrators in the seven Global Network sites. This work was supported by grants (U01 HD040477, U01HD040636, U10HD078437, U10HD076461, U10HD076465, U10HD076457, U10HD078439, U10HD078438, and U10HD076474) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the US National Institutes of Health United State of America.
Publisher Copyright:
© 2015 Marete et al; licensee BioMed Central Ltd.
PY - 2015/6/8
Y1 - 2015/6/8
N2 - Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.
AB - Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.
KW - Community based registry
KW - Lost to follow up rate
KW - Maternal and newborn registry
KW - Maternal socio demographic characteristics
KW - Pregnancy outcomes
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U2 - 10.1186/1742-4755-12-S2-S4
DO - 10.1186/1742-4755-12-S2-S4
M3 - Review article
C2 - 26062899
AN - SCOPUS:84977482249
SN - 1742-4755
VL - 12
JO - Reproductive health
JF - Reproductive health
IS - 2
M1 - S4
ER -