Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant

Joshua Stripling; Ranjit Kumar; John W. Baddley; Anoma Nellore; Paula Dixon; Donna Howard; Travis Ptacek; Elliot J. Lefkowitz; Jose A. Tallaj; William H. Benjamin; Casey D. Morrow; J. Martin Rodriguez

doi:10.1093/ofid/ofv078

Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant

Joshua Stripling
, Ranjit Kumar
, John W. Baddley
, Anoma Nellore
, Paula Dixon
, Donna Howard
, Travis Ptacek
, Elliot J. Lefkowitz
, Jose A. Tallaj
, William H. Benjamin
, Casey D. Morrow
, J. Martin Rodriguez

Research output: Contribution to journal › Article › peer-review

Abstract

We report the use of fecal microbiota transplantation in a single heart-kidney transplant recipient with recurrent Clostridium difficile, vancomycin-resistant Enterococcus (VRE) fecal dominance, and recurrent VRE infections. Fecal microbiota transplantation resulted in the reconstruction of a diverse microbiota with (1) reduced relative abundance of C difficile and VRE and (2) positive clinical outcome.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofv078
State	Published - Apr 1 2015
Externally published	Yes

Keywords

C difficile
Fecal microbiota transplant
Gut microbiome
Vancomycin-resistant Enterococcus
VRE

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofv078

Cite this

Stripling, J., Kumar, R., Baddley, J. W., Nellore, A., Dixon, P., Howard, D., Ptacek, T., Lefkowitz, E. J., Tallaj, J. A., Benjamin, W. H., Morrow, C. D., & Rodriguez, J. M. (2015). Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant. Open Forum Infectious Diseases, 2(2). https://doi.org/10.1093/ofid/ofv078

Stripling, J, Kumar, R, Baddley, JW, Nellore, A, Dixon, P, Howard, D, Ptacek, T, Lefkowitz, EJ, Tallaj, JA, Benjamin, WH, Morrow, CD & Rodriguez, JM 2015, 'Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant', Open Forum Infectious Diseases, vol. 2, no. 2. https://doi.org/10.1093/ofid/ofv078

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title = "Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant",

abstract = "We report the use of fecal microbiota transplantation in a single heart-kidney transplant recipient with recurrent Clostridium difficile, vancomycin-resistant Enterococcus (VRE) fecal dominance, and recurrent VRE infections. Fecal microbiota transplantation resulted in the reconstruction of a diverse microbiota with (1) reduced relative abundance of C difficile and VRE and (2) positive clinical outcome.",

keywords = "C difficile, Fecal microbiota transplant, Gut microbiome, Vancomycin-resistant Enterococcus, VRE",

author = "Joshua Stripling and Ranjit Kumar and Baddley, \{John W.\} and Anoma Nellore and Paula Dixon and Donna Howard and Travis Ptacek and Lefkowitz, \{Elliot J.\} and Tallaj, \{Jose A.\} and Benjamin, \{William H.\} and Morrow, \{Casey D.\} and Rodriguez, \{J. Martin\}",

note = "Publisher Copyright: {\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America.",

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doi = "10.1093/ofid/ofv078",

language = "English (US)",

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AU - Stripling, Joshua

AU - Kumar, Ranjit

AU - Baddley, John W.

AU - Nellore, Anoma

AU - Dixon, Paula

AU - Howard, Donna

AU - Ptacek, Travis

AU - Lefkowitz, Elliot J.

AU - Tallaj, Jose A.

AU - Benjamin, William H.

AU - Morrow, Casey D.

AU - Rodriguez, J. Martin

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AB - We report the use of fecal microbiota transplantation in a single heart-kidney transplant recipient with recurrent Clostridium difficile, vancomycin-resistant Enterococcus (VRE) fecal dominance, and recurrent VRE infections. Fecal microbiota transplantation resulted in the reconstruction of a diverse microbiota with (1) reduced relative abundance of C difficile and VRE and (2) positive clinical outcome.

KW - C difficile

KW - Fecal microbiota transplant

KW - Gut microbiome

KW - Vancomycin-resistant Enterococcus

KW - VRE

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Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant

Abstract

Keywords

ASJC Scopus subject areas

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