Loss of ADAMTS19 causes progressive non-syndromic heart valve disease

Keyphrases

• Nonsyndromic 100%
• ADAM19 100%
• Heart Valve Diseases 100%
• Knock-in Mouse Model 66%
• Valvular Interstitial Cells 66%
• Transcription Factor 33%
• Endocardium 33%
• Disease Manifestations 33%
• Whole Exome Sequencing 33%
• Affected Family Members 33%
• Tight 33%
• Human Phenotypes 33%
• Wnt Signaling Pathway 33%
• Aortic Valve Disease 33%
• Gene Regulatory Network 33%
• Valvular Heart Disease 33%
• Monogenic 33%
• Aortic Valve 33%
• Expression Analysis 33%
• LEF1 33%
• LacZ Reporter 33%
• Consanguineous Family 33%
• Mitral Valve Disease 33%
• Cell Position 33%
• Hemodynamic Perturbations 33%
• Nonsense Allele 33%
• Single-cell RNA Sequencing (scRNA-seq) 33%

Biochemistry, Genetics and Molecular Biology

• Knockout Mouse 100%
• Allele 50%
• Hemodynamic 50%
• Transcription Factors 50%
• Upregulation 50%
• Exome Sequencing 50%
• Maturation 50%
• Wnt Signaling Pathway 50%
• Gene Regulatory Network 50%
• RNA Sequence 50%
• Expression Analysis 50%
• Lymphoid Enhancer-Binding Factor 1 50%