Longitudinal Study of the Effects of Maternal Smoking on Pulmonary Function in Children

Ira B. Tager, Scott T. Weiss, Alvaro Muñoz, Bernard Rosner, Frank E. Speizer, Ira B. Tager, Alvaro Muñoz, Frank E. Speizer

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276 Scopus citations


We investigated the effects of maternal cigarette smoking on pulmonary function in a cohort of children and adolescents observed prospectively for seven years. A multivariate analysis revealed that after correction for previous forced expiratory volume in one second (FEV1), age, height, change in height, and cigarette smoking in the child or adolescent, maternal cigarette smoking significantly lowered the expected average annual increase in FEV1 (P = 0.015). On the basis of this analysis, it is estimated that if two children have the same initial FEV1, age, height, increase in height, and personal cigarette-smoking history, but the mother of one has smoked throughout the child's life whereas the mother of the other has not, the difference in the change in FEV1 over time in the exposed child, as compared with that in the unexposed child, will be approximately 28, 51, and 101 ml after one, two, and five years, respectively, or a reduction of 10.7,9.5, and 7.0 per cent, respectively, in the expected increase. These results suggest that passive exposure to maternal cigarette smoke may have important effects on the development of pulmonary function in children. (N Engl J Med 1983; 309:699–703.).

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalNew England Journal of Medicine
Issue number12
StatePublished - Sep 22 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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