TY - JOUR
T1 - Longitudinal study of depressive symptoms and health-related quality of life during pregnancy and after delivery
T2 - The health status in pregnancy (HIP) study
AU - Setse, Rosanna
AU - Grogan, Ruby
AU - Pham, Luu
AU - Cooper, Lisa A.
AU - Strobino, Donna
AU - Powe, Neil R.
AU - Nicholson, Wanda
N1 - Funding Information:
Dr. Nicholson was funded, in part, by the American Gynecological and Obstetrical Society. Drs. Nicholson and Powe are supported, in part, by the National Institute for Diabetes and Digestive and Kidney Diseases (Grant numbers: 1K23 DK-067944-01 to Dr. Nicholson; 2K24 DKO2643-06A1 to Dr. Powe).
PY - 2009
Y1 - 2009
N2 - Objective: Depressive symptoms are known to affect functioning in early pregnancy. We estimated the effect of a change in depressive symptoms status on health-related quality of life (HRQoL) throughout pregnancy and after delivery. Methods: Longitudinal study of 200 women. The independent variable was depressive symptoms, defined as a Center for Epidemiologic Studies Depression (CES-D) score of ≥16. The dependent variable was HRQoL from 8 domains of the Medical Outcomes Study (SF-36) Short Form. Women were categorized based on the change in CES-D score: (1) never depressed, (2) became well, (3) became depressed and (4) always depressed. A random effects model was used to (1) estimate the effect of a change in depressive symptomatology from the first to the second trimester on HRQOL in the second trimester and (2) estimate the change in depressive symptomatology from the second to the third trimester on HRQoL in the third trimester and after delivery, adjusting for covariates. Intra-individual correlations were accounted for using generalized estimating equations (GEE). Results: The proportion of women with depressive symptoms was 15%, 14%, and 30% in the first, second and third trimesters, respectively, and 9% after delivery. Women who became depressed had scores in the social domains that were 10-23 points and 19-31 points lower in the second and third trimesters, respectively, compared to women with no depressive symptoms. Women who became well had scores that were 3-31 points lower, compared to women with no depressive symptoms. Conclusions: Alterations in depressive symptomatology have a substantial effect on functioning during pregnancy and after delivery.
AB - Objective: Depressive symptoms are known to affect functioning in early pregnancy. We estimated the effect of a change in depressive symptoms status on health-related quality of life (HRQoL) throughout pregnancy and after delivery. Methods: Longitudinal study of 200 women. The independent variable was depressive symptoms, defined as a Center for Epidemiologic Studies Depression (CES-D) score of ≥16. The dependent variable was HRQoL from 8 domains of the Medical Outcomes Study (SF-36) Short Form. Women were categorized based on the change in CES-D score: (1) never depressed, (2) became well, (3) became depressed and (4) always depressed. A random effects model was used to (1) estimate the effect of a change in depressive symptomatology from the first to the second trimester on HRQOL in the second trimester and (2) estimate the change in depressive symptomatology from the second to the third trimester on HRQoL in the third trimester and after delivery, adjusting for covariates. Intra-individual correlations were accounted for using generalized estimating equations (GEE). Results: The proportion of women with depressive symptoms was 15%, 14%, and 30% in the first, second and third trimesters, respectively, and 9% after delivery. Women who became depressed had scores in the social domains that were 10-23 points and 19-31 points lower in the second and third trimesters, respectively, compared to women with no depressive symptoms. Women who became well had scores that were 3-31 points lower, compared to women with no depressive symptoms. Conclusions: Alterations in depressive symptomatology have a substantial effect on functioning during pregnancy and after delivery.
KW - Depressive symptoms
KW - Health-related quality of life
KW - Longitudinal analysis
KW - Pregnancy
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U2 - 10.1007/s10995-008-0392-7
DO - 10.1007/s10995-008-0392-7
M3 - Article
C2 - 18931832
AN - SCOPUS:68349093864
SN - 1092-7875
VL - 13
SP - 577
EP - 587
JO - Maternal and Child Health Journal
JF - Maternal and Child Health Journal
IS - 5
ER -