Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

S. Markovic-Plese; B. Bielekova; N. Kadom; T. P. Leist; R. Martin; J. A. Frank; H. F. McFarland

Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

S. Markovic-Plese, B. Bielekova, N. Kadom, T. P. Leist, R. Martin, J. A. Frank, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

Abstract

An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

Original language	English (US)
Pages (from-to)	1849-1851
Number of pages	3
Journal	Neurology
Volume	60
Issue number	11
State	Published - Jun 10 2003
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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abstract = "An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).",

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AU - Markovic-Plese, S.

AU - Bielekova, B.

AU - Kadom, N.

AU - Leist, T. P.

AU - Martin, R.

AU - Frank, J. A.

AU - McFarland, H. F.

PY - 2003/6/10

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N2 - An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

AB - An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

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JF - Neurology

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ER -

Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

Abstract

ASJC Scopus subject areas

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