Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

S. Markovic-Plese; B. Bielekova; N. Kadom; T. P. Leist; R. Martin; J. A. Frank; H. F. McFarland

Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

S. Markovic-Plese, B. Bielekova, N. Kadom, T. P. Leist, R. Martin, J. A. Frank, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

Abstract

An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

Original language	English (US)
Pages (from-to)	1849-1851
Number of pages	3
Journal	Neurology
Volume	60
Issue number	11
State	Published - Jun 10 2003
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

Cite this

@article{e3391aaf304444f89a7ec405a28f8df0,

title = "Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b",

abstract = "An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).",

author = "S. Markovic-Plese and B. Bielekova and N. Kadom and Leist, {T. P.} and R. Martin and Frank, {J. A.} and McFarland, {H. F.}",

year = "2003",

month = jun,

day = "10",

language = "English (US)",

volume = "60",

pages = "1849--1851",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - Longitudinal MRI study

T2 - The effects of azathioprine in MS patients refractory to interferon β-1b

AU - Markovic-Plese, S.

AU - Bielekova, B.

AU - Kadom, N.

AU - Leist, T. P.

AU - Martin, R.

AU - Frank, J. A.

AU - McFarland, H. F.

PY - 2003/6/10

Y1 - 2003/6/10

N2 - An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

AB - An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon β-1b (IFNβ-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNβ-1b-treated MS patients with continued disease activity were studied on IFNβ-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

UR - http://www.scopus.com/inward/record.url?scp=0038115303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038115303&partnerID=8YFLogxK

M3 - Article

C2 - 12796549

AN - SCOPUS:0038115303

SN - 0028-3878

VL - 60

SP - 1849

EP - 1851

JO - Neurology

JF - Neurology

IS - 11

ER -

Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon β-1b

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this