TY - JOUR
T1 - Longitudinal Changes over 10 Years in Free Testosterone among HIV-Infected and HIV-Uninfected Men
AU - for the Multicenter AIDS Cohort Study (MACS)
AU - Slama, Laurence
AU - Jacobson, Lisa P.
AU - Li, Xiuhong
AU - Palella, Frank J.
AU - Margolick, Joseph B.
AU - Kingsley, Lawrence A.
AU - Wiley, Dorothy J.
AU - Pialoux, Gilles
AU - Dobs, Adrian S.
AU - Brown, Todd T.
AU - Bream, Jay
AU - Crain, Barbara
AU - Elion, Richard
AU - Estrella, Michelle
AU - Johnson-Hill, Lisette
AU - Leng, Sean
AU - Monroe, Anne
AU - Munro, Cynthia
AU - Plankey, Michael W.
AU - Post, Wendy
AU - Sacktor, Ned
AU - Schrack, Jennifer
AU - Thio, Chloe
AU - Wolinsky, Steven M.
AU - Phair, John P.
AU - Badri, Sheila
AU - Gabuzda, Dana
AU - Penugonda, Sudhir
AU - Reddy, Susheel
AU - Stephens, Matthew
AU - Teplin, Linda
AU - Detels, Roger
AU - Martínez-Maza, Otoniel
AU - Aronow, Aaron
AU - Anton, Peter
AU - Bolan, Robert
AU - Breen, Elizabeth
AU - Butch, Anthony
AU - Hussain, Shehnaz
AU - Jamieson, Beth
AU - D'Souza, Gypsyamber
AU - Althoff, Keri
AU - Deal, Jennifer
AU - Duggal, Priya
AU - Haberlen, Sabina
AU - Muoz, Alvaro
AU - Ng, Derek
AU - Seaberg, Eric C.
AU - Su, Sol
AU - Surkan, Pamela
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Aging in males is associated with lower testosterone levels and a decrease in diurnal variation of testosterone secretion. Cross-sectional studies have shown lower than expected testosterone levels among HIV-infected men, but whether age-related changes in serum testosterone differ by HIV serostatus are not known. Methods: HIV-infected men from the Multicenter AIDS Cohort Study (MACS), age ≥45 years at highly active antiretroviral therapy initiation, who had ≥2 samples from the subsequent 10 years, were matched to HIV-uninfected men by age, race, MACS site, and calendar time of samples. Linear mixed-effects regression models were used to determine whether free testosterone (FT) and its rate of change differed by HIV serostatus. Results: One hundred eighty-two HIV-infected and 267 HIV-uninfected men were included, median age: 48.8 years (interquartile range: 45.8-53.4), median numbers of FT measurements per participant 4 (interquartile range: 3-5), 65% were drawn in the adjusted morning (AM). Mean-adjusted FT levels were lower among HIV-infected than HIV-uninfected men in AM samples {-6.1 ng/dL [95% confidence interval (CI): -9.8 to -2.4], P 0.001}, but not in afternoon samples [-1.7 ng/dL (-6.0 to 2.6), P 0.441]. The rate of FT decline with age did not differ by HIV serostatus: 9.2 ng/dL (95% CI: -13.4 to -5.0) per 10 years for HIV-infected vs. 7.9 ng/dL (95% CI: -10.2 to -5.5) for HIV-uninfected men, P 0.578. Conclusions: FT decreased similarly with increasing age regardless of HIV serostatus. The lower AM, but not adjusted afternoon, FT levels among HIV-infected men compared with HIV-uninfected men suggest a loss of diurnal variation in FT levels among HIV-infected men.
AB - Background: Aging in males is associated with lower testosterone levels and a decrease in diurnal variation of testosterone secretion. Cross-sectional studies have shown lower than expected testosterone levels among HIV-infected men, but whether age-related changes in serum testosterone differ by HIV serostatus are not known. Methods: HIV-infected men from the Multicenter AIDS Cohort Study (MACS), age ≥45 years at highly active antiretroviral therapy initiation, who had ≥2 samples from the subsequent 10 years, were matched to HIV-uninfected men by age, race, MACS site, and calendar time of samples. Linear mixed-effects regression models were used to determine whether free testosterone (FT) and its rate of change differed by HIV serostatus. Results: One hundred eighty-two HIV-infected and 267 HIV-uninfected men were included, median age: 48.8 years (interquartile range: 45.8-53.4), median numbers of FT measurements per participant 4 (interquartile range: 3-5), 65% were drawn in the adjusted morning (AM). Mean-adjusted FT levels were lower among HIV-infected than HIV-uninfected men in AM samples {-6.1 ng/dL [95% confidence interval (CI): -9.8 to -2.4], P 0.001}, but not in afternoon samples [-1.7 ng/dL (-6.0 to 2.6), P 0.441]. The rate of FT decline with age did not differ by HIV serostatus: 9.2 ng/dL (95% CI: -13.4 to -5.0) per 10 years for HIV-infected vs. 7.9 ng/dL (95% CI: -10.2 to -5.5) for HIV-uninfected men, P 0.578. Conclusions: FT decreased similarly with increasing age regardless of HIV serostatus. The lower AM, but not adjusted afternoon, FT levels among HIV-infected men compared with HIV-uninfected men suggest a loss of diurnal variation in FT levels among HIV-infected men.
KW - Free testosterone
KW - HIV-status
KW - aging
KW - diurnal variation
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U2 - 10.1097/QAI.0000000000000821
DO - 10.1097/QAI.0000000000000821
M3 - Article
C2 - 26761271
AN - SCOPUS:84951165990
SN - 1525-4135
VL - 71
SP - 57
EP - 64
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
IS - 1
ER -