TY - JOUR
T1 - Longitudinal changes in cortical thickness associated with normal aging
AU - Thambisetty, Madhav
AU - Wan, Jing
AU - Carass, Aaron
AU - An, Yang
AU - Prince, Jerry L.
AU - Resnick, Susan M.
N1 - Funding Information:
This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging . Partial support was provided by the National Institute of Neurological Disorders and Stroke (NINDS) , a part of the National Institute of Health (NIH), through grants R01-NS37747 , RO1-AG016324 and R01-NS054255 . The authors have no known conflicts of interest. The atlas data was provided by Dr. Bruce Fischl, Martinos Center for Biomedical Imaging, and supported by the NCRR through grants P41-RR14075 and R01 RR16594-01A1 and by the NIH/NINDS through grant R01 NS052585-01 . We are grateful to the BLSA participants and neuroimaging staff for their dedication to these studies.
PY - 2010/10
Y1 - 2010/10
N2 - Imaging studies of anatomic changes in regional gray matter volumes and cortical thickness have documented age effects in many brain regions, but the majority of such studies have been cross-sectional investigations of individuals studied at a single point in time. In this study, using serial imaging assessments of participants in the Baltimore Longitudinal Study of Aging (BLSA), we investigate longitudinal changes in cortical thickness during aging in a cohort of 66 older adults (mean age 68.78; sd. 6.6; range 60-84 at baseline) without dementia. We used the Cortical Reconstruction Using Implicit Surface Evolution CRUISE suite of algorithms to automatically generate a reconstruction of the cortical surface and identified twenty gyral based regions of interest per hemisphere. Using mixed effects regression, we investigated longitudinal changes in these regions over a mean follow-up interval of 8. years. The main finding in this study is that age-related decline in cortical thickness is widespread, but shows an anterior-posterior gradient with frontal and parietal regions, in general, exhibiting greater rates of decline than temporal and occipital. There were fewer regions in the right hemisphere showing statistically significant age-associated longitudinal decreases in mean cortical thickness. Males showed greater rates of decline in the middle frontal, inferior parietal, parahippocampal, postcentral, and superior temporal gyri in the left hemisphere, right precuneus and bilaterally in the superior parietal and cingulate regions. Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right.
AB - Imaging studies of anatomic changes in regional gray matter volumes and cortical thickness have documented age effects in many brain regions, but the majority of such studies have been cross-sectional investigations of individuals studied at a single point in time. In this study, using serial imaging assessments of participants in the Baltimore Longitudinal Study of Aging (BLSA), we investigate longitudinal changes in cortical thickness during aging in a cohort of 66 older adults (mean age 68.78; sd. 6.6; range 60-84 at baseline) without dementia. We used the Cortical Reconstruction Using Implicit Surface Evolution CRUISE suite of algorithms to automatically generate a reconstruction of the cortical surface and identified twenty gyral based regions of interest per hemisphere. Using mixed effects regression, we investigated longitudinal changes in these regions over a mean follow-up interval of 8. years. The main finding in this study is that age-related decline in cortical thickness is widespread, but shows an anterior-posterior gradient with frontal and parietal regions, in general, exhibiting greater rates of decline than temporal and occipital. There were fewer regions in the right hemisphere showing statistically significant age-associated longitudinal decreases in mean cortical thickness. Males showed greater rates of decline in the middle frontal, inferior parietal, parahippocampal, postcentral, and superior temporal gyri in the left hemisphere, right precuneus and bilaterally in the superior parietal and cingulate regions. Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right.
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U2 - 10.1016/j.neuroimage.2010.04.258
DO - 10.1016/j.neuroimage.2010.04.258
M3 - Article
C2 - 20441796
AN - SCOPUS:77954952162
SN - 1053-8119
VL - 52
SP - 1215
EP - 1223
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -